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2010-2011 Catalog Online

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Biochemistry (BCH)

Chairperson: Professor Sperry (Cell and Molecular Biology)

190 Issues in Biotechnology (3)

See Aquaculture and Fisheries Science 190. (N)

211 Biochemical Aspects of Nutrition and Physiology (3)

Chemistry of biological transformations in the cell. Chemistry of carbohydrates, fats, proteins, enzymes, vitamins and hormones integrated into a general discussion of energy-yielding and biosynthetic reactions in the cell. (Lec. 3) Pre: one year college biology and one year of chemistry including CHM 124.

242 Human Genetics and Human Affairs (3)

Basic principles of genetics including patterns of inheritance, mitosis and meiosis, sex determination and sex linkage. Genetic diseases, their cause and cures. Recombinant DNA and genetic engineering. Human diversity and evolution. (Lec. 3)

311 Introductory Biochemistry (3)

Chemistry of biological transformations in the cell. Chemistry of carbohydrates, fats, proteins, nucleic acids, enzymes, vitamins, and hormones integrated into a general discussion of the energy-yielding and biosynthetic reactions in the cell. (Lec. 3) Pre: CHM 124 or equivalent.

312 Introductory Biochemistry Laboratory (2)

Laboratory exercises illustrate chemical and physical properties of biomolecules, separation techniques, enzyme catalysis, symptoms of nutritional deficiency, quantification of metabolic end-products, and drug detoxification. (Lab. 4) Pre: credit or concurrent enrollment in 311.

352 General Genetics

See Biological Sciences 352.

353 (or BIO 353) Genetics Laboratory (1)

Basic principles and concepts of genetics demonstrated with microorganisms, plants and animals. (Lab. 2) Pre: credit or concurrent enrollment in 352.

412 Biochemistry Laboratory (3)

Same as 312 plus an individual supervised laboratory project selected in consultation with the student. Projects may include enzyme action, enzyme induction, drug action, use of radioisotopes, and plant metabolism. (Lab. 6) Pre: credit or concurrent enrollment in 311.

435 (or MIC 435) Introduction to the Biology and Genetics of Cancer (3)

Comprehensive instruction in the biology, genetics and biochemistry of cellular transformation and cancer. Pre: 311 and 352, or permission of instructor.

437 Fundamentals of Molecular Biology

See Biological Sciences 437.

451 (or MIC 451) Laboratory in Cell Biology (1)

Analysis of subcellular processes, structures, and molecules using techniques including gel electrophoresis, spectrophotometry ultracentrifugation, and protein purification. Topics range from analysis of gene expression to subcellular localization of enzymatic activity. (Lab. 2) Pre: concurrent enrollment in 453 (or MIC 453) or permission of instructor.

452 (or BIO 452) Advanced Topics in Genetics (3)

More detailed treatment of topics introduced in the general genetics course (352) including aspects of transmission genetics, molecular genetics, cytogenetics, biotechnology, developmental genetics, and the impact of genetics on society. (Lec. 3) Pre: BIO 352.

453 Cell Biology

See Biological Sciences 453.

464 Biochemistry of Metabolic Disease (3)

A study of the primary and secondary molecular changes in human metabolic diseases. Topics include aging, alcoholism, arteriolosclerosis, diabetes, depression, and genetic diseases. (Lec. 3) Pre: 311 or 481.

484 Physical Methods in Biochemistry (3)

Experimental methods including spectroscopy, spectrofluorimetry, optical rotation, chromatography, and electrophoresis are applied to biochemical compounds and reactions. Physical principles and the calculation of important properties are stressed. (Lec. 1, Lab. 4) Pre: 435, 481, and permission of chairperson.

491, 492 Research in Biochemistry (1-6 each)

Special problems. Student outlines the problem, carries on experimental work, presents the conclusions in a report. (Independent Study) Pre: permission of instructor. Not for graduate credit in biochemistry.

495, 496 Biochemistry Seminar (1 each)

Discussion and presentation of research papers on selected subjects in biochemistry. (Lec. 1) Pre: 311, 482, or 582.

500 Principles and Techniques in Molecular Cloning (II, 2)

Current techniques and strategies in gene cloning, characterization, construction, and expression in prokaryotes and eukaryotes. Comprehensive knowledge and understanding necessary for gene cloning and vector construction emphasized (Lec. 2). Pre: 437 or permission of instructor.

502 Techniques of Molecular Biology

See Microbiology 502.

508 Seminar in Biological Literature

See Biological Sciences 508.

521 Physical Biochemistry (3)

The use of calorimetry, centrifugation, electrophoresis, (SDS-PAGE, agarose gels, sequencing gels, immunoelectrophoresis, capillary electrophoresis, and isoelectric focusing), chromatography (GFC, SPX, IEX, normal and reversed-phase HPLC, and micro-HPLC), mass spectrometry (ion-labeling, MALDI, FAB, electrospray, and MS/MS), radioactive labels, and X-ray crystallography to characterize biologically important macromolecules such as proteins, DNA/RNA, carbohydrates, and lipids. (Lec. 3) Pre: 311, concurrent registration in 581, or permission of instructor. In alternate years. Next offered fall 2012.

522 Bioinformatics I

See Biomedical and Pharmaceutical Sciences 542.

523, 524 Special Topics in Biochemistry (1-3 each)

Advanced work arranged to suit the individual needs of the student. Lecture and/or laboratory according to the nature of the problem. (Independent Study) Pre: permission of chairperson. May be repeated for a maximum of 12 credits. S/U credit for 524.

551 (or MLS 551) Topics in Biochemistry for the Clinical Scientist (3)

Description of the major components of biochemistry as it relates to the medical sciences. Major concepts include molecular genetics, regulatory biochemistry, and medically related applied biochemistry. (Lec. 3) Offered every third year.

552 Microbial Genetics

See Microbiology 552.

579 Advanced Genetics Seminar

See Biological Sciences 579.

581 General Biochemistry I (3)

First semester of a two-semester course on the principles of biochemistry. Topics include bioenergetics, protein structure, enzymology, glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation. (Lec. 3) Pre: CHM 228 and 229.

582 General Biochemistry II (3)

Second semester of a two-semester course on the principles of biochemistry. Topics include photosynthesis, membranes, hormones, metabolism, the biosynthesis of DNA, RNA, and proteins. (Lec. 3) Pre: 581 or permission of instructor.

585 Recent Advances in Receptor Research (1)

Discussion of current research literature about receptors for hormones, pheromones, neurotransmitters, and other biological signals. Consequences of receptor activation will also be discussed. (Lec. 1) Pre: 311 and permission of instructor. May be repeated.

599 Master’s Thesis Research

Number of credits is determined each semester in consultation with the major professor or program committee. (Independent Study) S/U credit.

642 Biochemical Toxicology

See Biomedical and Pharmaceutical Sciences 642.

651, 652 Research in Biochemistry (3 each)

Students are required to outline a research problem, conduct necessary literature survey and experimental work, and present the observations and conclusions in a substantial written report. (Independent Study) Pre: graduate standing.

695, 696 Graduate Seminar

See Microbiology 695, 696.

699 Doctoral Dissertation Research

Number of credits is determined each semester in consultation with the major professor or program committee. (Independent Study) S/U credit.

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