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2010-2011 Catalog Online

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Biomedical and Pharmaceutical Sciences (BPS)

Chairperson: Professor Chichester

201 How Drugs Work (3)

Drug actions, uses, and adverse effects of prescription and non-prescription medications, recreational drugs, and nutritional supplements. General audience: (Lec. 3) Open to all students except health science and related majors. (N)

202 Maintaining Health in the Age of Chemicals /(2)

Introduction for the general student to the potential hazards posed by drugs, food additives, and pollutants to the maintenance of health. (Lec. 2) Not for program credit for nursing or pharmacy majors in the third year or beyond.

203 Herbal Medicines and Functional Food (3)

Study of traditional herbal medicines, commonly used medicinal plants, and modern plant-derived drugs. Medicinal foods, herbal supplements, and plant extracts (nutraceuticals) for health benefits beyond basic nutrition. (Lec. 3) Intended for freshmen and sophomores. (N)

301 Dosage Forms I: Regulation of Drug Products and Biopharmaceutics (2)

Introduction to the regulation of drug products. Application of kinetics to stability, dissolution, absorption, and other biopharmaceutical process. Bioavailability and generic equivalence. (Lec. 2) Open to BSPS students third year standing and CHE students in pharmaceutical track

303 Dosage Forms II: Solid and Solution Dosage Forms and Pharmaceutical Calculations (2)

Physicochemical properties of drug molecules and their effect on formulation, manufacturing, and administration of solid and solution products. Introduction to pharmaceutical calculations. (Lec. 2) Open to Open to BSPS students third year standing and CHE students in pharmaceutical track.

305 Dosage Forms III: Disperse System, Sterile and Specialty Dosage Forms (2)

Physicochemical properties of drug molecules and their effect on formulation, manufacturing, and administration of Disperse System, Sterile and Specialty Dosage Forms. (Lec. 2) Open to BSPS students third year standing and CHE students in pharmaceutical track.

310 Foundations

See Pharmacy Practice 310.

311 (or PHP 311) Foundations of Human Disease I: Immunoinflammatory Disease (2)

The pathogenesis, etiology, epidemiology, symptomatology, and diagnosis of immunoinflammatory and musculo-skeletal diseases. The pharmacology and medicinal chemistry of anti-inflammatory medications, immunosuppressives, and anti-rheumatic drugs. (Lec. 2) Pre: third-year standing or permission of instructor. Open to BSPS students. Offered every fall.

313 Principles of Medicinal Chemistry (2)

Physico-chemical properties of drug molecules; and principles needed to understand chemical basis of pharmacology and therapeutics, pharmacophores for drugs used to treat disease, and structure-activity relationships of drug-target interactions. Open to BSPS students.

318 Pharmacy Technology Laboratory (1)

Prescription processing and compounding techniques for pharmaceutical dosage forms. (Lab. 3) Pre: third-year standing or permission of instructor.

321 Principles of Pharmacology and Autonomic Pharmacology (2)

Fundamental principles of drug action with emphasis on drug/receptor interactions. Mechanisms of action and medicinal chemistry of drugs that affect the autonomic nervous system. (Lec. 2) Pre: third-year standing or permission of instructor. Open to BSPS students. Offered every fall.

322 Pharmacology and Medicinal Chemistry of Drugs Acting on the Central Nervous System (2)

Neurologic agents in the brain; antidepressants, antipsychotics, sedative hypnotics, analgesics, anti-seizure medications, anti-dementia therapy, and anti-anxiety medications. (Lec. 2) Pre: third-year standing or permission of instructor. Offered every spring.

325 Drug Metabolism and Bioanalysis (2)

Chemical, biochemical, genetic and clinical aspects of drug metabolism. Examples of modern bioanalysis and clinical chemistry and its importance to screening, diagnosis and evaluation of patients (Lec. 2) Pre: third-year standing or permission of instructor. Offered every spring.

326 Pharmacology and Medicinal Chemistry Laboratory I (1)

Effects of drugs on physiological functions. Identification and quantification of drugs and their actions. (Lab. 3) Pre: third-year standing or permission of instructor. Offered every spring.

333 Nursing Pharmacology (3)

Comprehensive course in nursing pharmacology that forms the basis for therapeutics. (Lec. 3) Pre: NUR 213 and 234, or RN student status or permission of instructor.

334 Pharmacology and Medicinal Chemistry of Cardiovascular and Renal Drugs (2)

Mechanism of action, adverse effects, and therapeutic applications of drugs affecting cardiovascular and renal function. (Lec. 2) Pre: doctor of pharmacy professional student in good standing; or permission of instructor.

340 (or AVS 340) Veterinary Pharmacology (3)

Principles of pharmacology including pharmacokinetics and pharmacodynamics, drug indications, usages and side effects, practical applications of drugs including drug handling, dosing calculation and administration methods. (Lec. 3) Pre for AVS students: AVS 331 and 333 or permission of instructor; Pre for BSPS and Pharm.D students: 2nd or 3rd year standing.

352 Personal Cosmetics (3)

Formulation and manufacture of various types of personal cosmetics and toilet preparations. Examples of types studied are prepared in laboratory. (Lec. 2, Lab. 3) Pre: third year standing.

403 Pharmacokinetics I (3)

Pharmacokinetics of drug distribution, metabolism, and elimination. Compartmental models, pharmacokinetic modeling, development of dosage regimens. (Lec. 3) Pre: fourth-year standing or permission of instructor.

405 Physical Pharmacy (3)

Provides an understanding of the basic principles behind the formulation, manufacturing, storage stability and bio-availability of drug products (Lec. 3) Pre: PHY 111, 185. Not for graduate credit.

409 (or PHP 409) Foundations of Human Disease III: Infectious and Pulmonary Processes (2)

The etiology, pathogenesis, epidemiology, symptomatology, and diagnosis of infections and pulmonary diseases. (Lec. 2) Pre: fourth-year standing or permission of instructor. Offered every fall.

410 Foundations for Human Disease V: GI, Endocrine (2)

See Pharmacy Practice 410.

411 Biostatistics II

See Statistics 411.

412 Foundations of Human Diseases: CNS

See Pharmacy Practice 412.

416 Pharmacology and Medicinal Chemistry Laboratory II (1)

Pharmacologic principles relating to the modification of drug activity and toxicity. Clinical assays relevant to assessing drug effects. (Lab. 3) Pre: fourth-year standing or permission of instructor. Offered every fall.

420 (or PHP 420) Biotechnology Products in Pharmacy (2)

Clinical, pharmaceutical, and economic impact of biotechnology products in pharmacy, including monoclonal antibodies, interleukins, human growth factors, antigens oligonucleotides, DNase, and interferons. (Lec. 2)

421 Pharmacology and Medicinal Chemistry of Anti-infective and Respiratory Agents (2)

Chemistry, mechanism of action, sensitivity, resistance, and toxicity of anti-infections drugs, and an overview of antibacterial, antifungal, antiviral, antiprotozoal, respiratory drugs, and vaccines in current use. (Lec. 2) Pre: fourth-year standing or permission of instructor. Offered every fall.

422 Endocrine, Gastrointestinal, and Biotechnologic Drugs (2)

Mechanisms of action of drugs used to treat endocrine and gastrointestinal disorders. Biological and biotechnologic sources, isolation, design, and medicinal chemistry of biopolymer drugs. (Lec. 2) Pre: fourth-year standing or permission of instructor. Offered every spring.

425 GMPs in the Manufacture of Pharmaceutical Products (3)

Application of current Good Manufacturing Practices to the manufacture and quality control of various pharmaceutical products. (Lec. 3) Pre: fourth year standing or permission of instructor. Open to CHE students in pharmaceutical track. Not for graduate credit.

432 (322) CNS Drug Pharmacology and Medicinal Chemistry (2)

The pharmacologic and biochemical action and side effects of drugs used to treat neurologic, psychiatric, and skeletal muscle system diseases. (Lec. 2) Pre: Doctor of Pharmacy student in good standing or permission of the instructor. Not for graduate credit. Offered every spring.

436 (or PSY 436) Psychotropic Drugs and Therapy /(3)

Interaction of drug and nondrug therapy and of physiological and psychological origins of psychopathology. Intended for advanced undergraduate and graduate students interested in clinical psychology. (Lec. 3) Pre: any one of the following: BIO 101, 104B, 113, 121, PSY 381, or permission of instructor. Not for graduate credit.

442 Pharmacogenetics and Pharmacogenomics (3)

Principles of how genetic and genomic factors contribute to individual variation in drug response and how these principles can be used to produce effective and safe drugs. (Lec. 3) Pre: BCH 311 and BPS 321.

443 Formulation and Manufacturing Laboratory (2)

Provides general principles and hands-on experience in the preformulation, formulation, manufacturing, and quality control fields that are necessary in design, formulation, compounding and manufacturing of drug dosage forms. (Lab. 4) Pre: 301 or 303 or 305.

445 Natural Products and Biotechnological Drugs /(3)

Natural drug products of biological or biotechnological origin. Sources, process of isolation or production, and general fundamental properties. (Lec. 3) Pre: CHM 228; MIC 201 or equivalent.

450 Practical Tools for Molecular Sequence Analysis

See Medical Laboratory Science 450.

451 Techniques in Medicinal Chemistry and Molecular Biology (4)

Provides students with an understanding of medicinal chemistry, molecular biology, and drug analysis techniques commonly used in pharmaceutical industry. The course combines laboratory exercises with easy-to-understand lectures. (Lec. 3, Lab. 4) Pre: BCH 311 and BPS 313 and 321.

455 Protein Molecular Modeling for Biomedical Sciences (3)

Use of cutting edge computer software to explore the 3D-structure of proteins of biomedical interest. Independent application of course topics will be required: either a case study to teach existing knowledge or a research project to create new knowledge. (Lec. 1, Lab 6) Pre: BCH 311 or equivalent with grade of B- or better, and CHM 227 (or 124) with grade of B- or better. Not for graduate credit.

497, 498 Special Problems (1-5 each)

Methods of carrying out a specific research project. Literature search, planning, laboratory work, writing an acceptable report. (Independent Study) Pre: permission of chairperson. Not for graduate credit.

503 Pharmacokinetics and Pharmacodynamics for Scientists (3)

Presents the principles of pharmacokinetics and pharmacodynamics with specific emphasis on their application in pharmaceutical science. Pre: MTH 131.

504 Pharmacokinetics II (3)

Applied pharmacokinetics, principles of clinical pharmacology, therapeutic drug monitoring, and dose individualization. (Lec. 3) Pre: 403, fifth year standing or permission of instructor. Offered every fall semester.

515 (or PHP 515) Pharmacy Practice Laboratory I (1)

Simulated practice sessions designed to develop the delivery of pharmaceutical care, including prescription processing, use of patient profiles, communication with patients and health care professionals, pharmaco-epidemiology, and physical assessment. (Lab. 3) Pre: fifth-year standing or permission of instructor.

516 (or PHP 516) Pharmacy Practice Laboratory /II /(1)

Simulated practice sessions designed to develop the delivery of pharmaceutical care, including prescription processing, use of patient profiles, communication with patients and health care professionals, pharmaco-epidemiology, and physical assessment. (Lab. 3) Pre: fifth-year standing or permission of instructor.

519 Self-Care II

See Pharmacy Practice 519.

521 Cancer Chemotherapy and Toxicology (3)

Pharmacology and medicinal chemistry of oncology drugs. Principles of toxicology. (Lec. 3) Pre: fifth-year standing or permission of instructor. Offered every /fall.

525 Experimental Techniques in Biomedical ≠Sciences (4)

Provides experience with a variety of techniques used in biomedical science research, including HPLC, NMR, polarimetry, biotransformations, solid-phase synthesis, cell fractionation, and isolation and purification of proteins. (Lab. 4)

526 Foundations of Human Disease VI: Hematology-Oncology

See Pharmacy Practice 526.

530 Drug Metabolism (3)

Mechanisms of Phase 1 (oxidation, reduction, hydrolysis) and Phase 2 (conjugations and synthesis) of drug metabolism. (Lec. 3) Pre: BCH 581 or permission of instructor. Offered every spring.

533 Medicinal Plants (3)

Problems in drug plant chemotaxonomy with field work in the drug plant gardens. Emphasis is placed on certain alkaloid, glycoside and oil-yielding plants, weedicides and insecticides as related to measures for control. (Lec. 2, Lab. 3) Pre: 446 or equivalent.

535 Pharmaceutical Biotechnology (3)

Introduction to pharmaceutical biotechnology, including drug design, DNA sequencing, cloning, recombinant proteins, monoclonal antibodies, and drug-screening techniques. (Lec. 3) Pre: BCH 581 or permission of instructor.

536 Biotechnology Product Evaluation and Development

See Medical Laboratory Science 571.

542 (or CSC 522 or MIC 522 or STA 522) Bioinformatics I

Integrates computing, statistical, and biological sciences, algorithms, and data analysis/management. Multidisciplinary student research teams. Modeling dynamic biological processes. Extra project work for 4 credits. (Lec. 3, Project 3) Pre: major in a computing, statistical, or biological science or permission of instructor.

544 Forensic Toxicology (3)

Theoretical and practical aspects of poisoning including the isolation and identification of toxic materials from pharmaceuticals, body fluids, and tissues. Isolation and identification of physiological fluids from stains, hairs, and tissue with application to forensic medicine. (Lec. 2, Lab. 3) Pre: permission of instructor.

545 Applied Toxicology (2)

A two-credit lecture course dealing with cases of common toxic syndromes caused by drug overdose or exposure to environmental agents. Antidotes/patient decontamination measures will be surveyed. Patient case studies will be discussed. (Lec. 2) Pre: 322, 455, 521 or permission of instructor.

546 Advanced Toxicology (3)

Toxic effects of selected drugs and other xenobiotics on physiological and biochemical processes. (Lec. 3) Pre: permission of instructor. Offered every third year. Next offered spring 2012.

550 Practical Tools for Molecular Sequence Analysis (3)

See Microbiology 550.true

551 Chemistry of Natural Products (3)

Introduction to chemistry of certain groups of natural products especially in relation to their chemotaxonomic position in plant classification. Topics limited to secondary metabolites; e.g., terpenoids, phenolic compounds, aromatic compounds, phytosterols, alkaloids. (Lec. 3) Pre: CHM 228 and 230. In alternate years. Next offered fall 2012.

552 Advanced Medicinal Chemistry (3)

Covers didactic topics of medicinal chemistry: Drug Discovery, Design, and Development; Drug-Receptor Interactions; Mechanisms of Enzyme Catalysis and Cofactors; Enzyme Inhibition and Inactivation; DNA Interactive Agents; Drug Metabolism; Prodrugs and Drug Delivery Systems. Pre: Introductory Organic Chemistry and permission of instructor.

560 Fundamentals of Cosmetic Science (3)

Study of the fundamentals of the function and behavior of skin, hair, and nails and their reactivity to cosmetic raw materials. Properties of cosmetic ingredients will also be addressed. (Lec. 3) Pre: permission of instructor.

561 Basic Research in Cosmetic Science (2)

Laboratory exercises in the form of individual projects designed to provide an understanding of the basic properties and behavior of skin, hair, and nails. Assessment of cosmetic product performance and the basic properties of cosmetic ingredients. (Lab.) Pre: permission of instructor.

562 Cosmetic Product Formulation (2)

Provides a basic understanding of cosmetic products, technology, and quality control; improves formulation skills with a particular emphasis on the application of new technological developments in cosmetic preparation. (Lab.) Pre: permission of instructor.

565 Pharmacokinetics (3)

The principles and application of clinical pharmacokinetics for advanced pharmacy students. Developing, modifying, and evaluating dosage regimens. (Lec. 3)

572 Neural Bases of Drug Action (3)

Review of neuroanatomy, neurochemistry, and neurophysiology as they relate to drug action. (Lec. 3) Pre: 322 or equivalent or permission of instructor. Offered every third year. Next offered spring 2012.

587 General Pharmacology (3)

An introduction to principles of pharmacology and major drug categories, for graduate students and advanced undergraduate students in biological sciences. (Lec. 3) Pre: permission of instructor.

597, 598 Special Problems (1-3 each)

Special graduate student project assignments in research under the supervision of faculty. (Independent Study) Pre: graduate standing. May be repeated for a maximum of 6 credits.

621 Manufacturing Pharmacy I (2)

Theory and practice in the manufacture of pharmaceuticals and the principles of operation of the equipment used for their production. (Lec. 2) In alternate years.

622 Manufacturing Pharmacy II (3)

Theories applied to the manufacture of pharmaceuticals with an emphasis on formulation considerations and principles of operation of equipment used for their production. (Lec. 3) Pre: 621. In alternate years.

623 Manufacturing Pharmacy Laboratory (2)

Practical application of the principles of all aspects of dose-form manufacture, including an emphasis on good manufacturing practices. (Lab.) Pre: credit or concurrent enrollment in 622.

625 Advanced Physical Pharmacy (4)

Theory and application of physical chemical principles to problems in pharmaceutical research, with emphasis on methods by which properties of new medicinal agents are determined. (Lec. 4) Pre: permission of instructor.

626 Advanced Physical Pharmacy Laboratory (1)

Laboratory exercises dealing with the physical-chemical principles used in the evaluation of pharmaceutical substances. (Lab. 4) Pre: permission of instructor.

633 Biosynthesis (3)

Biogenesis of medicinally active principles of biological origin. Emphasis given to organic acids, polysaccharides, glycosides, steroids, and certain nitrogenous compounds. (Lec. 3) In alternate years. Next offered spring 2013.

635, 636 Pharmacognosy Techniques (3-4 each)

Physical and chemical factors influencing growth and development of active principles of drug plants. Certain biological analyses of results are performed. (Lec. 1, Lab. 6-9)

641 Biochemical Pharmacology (3)

Theory and application of pharmacological studies at the cellular and subcellular levels and their significance to drug action in the intact organism. (Lec. 2, Lab. 3) Pre: permission of instructor. Offered every third year. Next offered fall 2011.

642 (or BCH 642) Biochemical Toxicology (3)

Biochemical and molecular aspects of chemically induced cell injury and chemical carcinogenesis. (Lec. 3) Pre: permission of instructor. Offered every third year. Next offered fall 2012.

644 Cardiovascular Pharmacology (3)

Cellular mechanisms of drug action as a basis for understanding therapeutic effects. Emphasis on current developments in antihypertensive, antiarrhythmic, antianginal, and cardiotonic drug research. (Lec. 3) Pre: permission of instructor. Offered every third year. Next offered spring 2012.

660 Industrial Project (Pharmaceutics) (3)

A research project directed by the major professor on a topic in industrial pharmacy. A report must be submitted to the department faculty. The project will normally be conducted off campus. (Lab.) Pre: graduate standing in pharmaceutics.

670 Advanced Pharmacokinetics (3)

Application of classical compartmental and noncompartmental analyses to pharmacokinetics and pharmacodynamics emphasizing the use of PKPD analysis employed in the pharmaceutical industry. Pre: 403 or permission of instructor. Graduate standing or in good standing in the P2-P4 years of the Pharm. D. curriculum.

691 Selected Topics in Medicinal Science (3)

Covers the following special research topics of interest: (a) heterocyclic chemistry, (b) nucleoside antibiotics, (c) prodrugs and isosteres, (d) nucleosides and nucleotides-synthesis and biological function, and (e) nucleic acid targeted drug design. (Lec. 3) Pre: permission of instructor. May be repeated for a maximum of 9 credits.

697, 698 Research in Biomedical and Pharmaceutical Sciences (1-3 each)

Literature survey, laboratory work, and a detailed research report on one or more assigned topics. (Independent Study)


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