Try to avoid the use of frames on all top-level pages or on all pages if possible.  Common trouble with frames include the following.

1. You cannot bookmark an individual framed page
You can only bookmark the home page of a Website that consists of frames. 

2. You cannot link to a framed page
It's not possible to correctly link to a page within frames. If you do link to it, anybody following the link will miss out on the other frames such as navigation controls.

3. Browsers can have problems with Back/Forward buttons

4. Framed sites are more difficult for text-based and speech browsers
        

5. Inexperienced designers can make all sorts of mistakes with frames

One of the most common problems of using frames is to show the effect of rows and columns. You can achieve the same effect with tables.  In fact tables do this job better and cleaner.

Another common problem is jamming lots of little frames onto the page. More than two or three frames creates a very cluttered page. There's so much noise and so many things going on that your readers will often just give up.