Remarks by US Senator Sheldon Whitehouse (RI), Member, US Senate Committee on Health, Education, Labor, and Pensions

Fred Taylor, IDeA Program Director, Division of Research Infrastructure, National Center for Research Resources, National Institute of Health, Bethesda, MD

8:15 - 9:00 PM

Updates on the Division of Research Infrastructure.  Yanping Liu, Program Officer, Centers for Biomedical Research Excellence , Division of Research Infrastructure, National Center for Research Resources, National Institutes of Health, Bethesda, MD

9:00 - 9:45 PM

Updates on Administrative Issues. Fred Taylor, IDeA Program Director, Division of Research Infrastructure, National Center for Research Resources, National Institute of Health, Bethesda, MD

9:45 - 10:00 PM

Panel Discussion

Scientific Session 1:  Cancer Biology

Room 260, O'Hare Academic Center

Chair: 

8:00 - 8:40 AM

NKG2D, an NK Cell Activating Receptor on CD8+ T Cells, Plays an Essential Role in Killing Myeloma Cells.  Lelah Talebian, Dawn Fischer, Marc Ernstoff, Kenneth Meehan, Blood and Marrow Transplant Program; Zbigniew Szczepiorkowski, Cellular Therapy; Dartmouth Hitchcock Medical Center, Lebanon, NH; Charles Sentman, Department of Microbiology and Immunology, Dartmouth College, Lebanon, NH

8:40 - 9:00 AM

MicroRNAs in Acute Myeloid Leukemia: Outcomes from Target and Profiling Based Studies.  Amanda Favreau and Pradeep Sathyanarayana, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

9:00 - 9:20 AM

CXCR4 and IGFR Regulate Neurite Outgrowth in Neuroblastoma Cells.  James Miller, Cynthia van Golen, Department of Biological Sciences; Chandra Sabanayagam, Department of Physics, Delaware State University, Dover, DE

9:20 - 9:40 AM

HDAC6 is a gatekeeper for survivin nuclear export in breast cancer.  Matthew Riolo, Zachary Cooper, Michael Holloway, Rachel Altura, Department of Pediatrics; Eugene Chin, Department of Surgical Research, Rhode Island Hospital, Providence, RI

9:40 - 10:00 AM

Comparing Enhancer Action in Cis and in Trans.  Jack Bateman and Justine Johnson, Department of Biology, Bowdoin College, Brunswick, ME

Scientific Session 2:  Immunobiology and Pathogenesis

Rooms 228-229, O'Hare Academic Center

Chair:

William Green, Department of Microbiology and Immunology, Dartmouth-Hitchcock Medical Center, Lebanon, NH

8:00 - 8:40 AM

Collateral Damage: Implications and Applications for AID-induced Genome Breaks.  Kevin Mills, Department of Immunology, Inflammation, and Hematology, Jackson Laboratory, Bar Harbor, ME, and Maine Medical Center Research Institute, Scarborough, ME

8:40 - 9:00 AM

Effects of Obesity and Weight Loss on Airways Hyperresponsiveness, Asthma Control, and Inflammation.  Anne Dixon, Richard Pratley, David Kaminsky, Laurie Whittaker-Leclair, Laurianne Griffes, Jayanathi Garudathi, Danielle Raymond, Matthew Poynter, Charles Irvin, Department of Medicine; Janice Bunn, Department of Medical Statistics, University of Vermont, Burlington, VT

9:00 - 9:20 AM

The Benefits of Being a Lazy Bug During Infection.  Brent Berwin, Rustin Lovewell, Deb Hogan, Bruce Stanton, George O’Toole, Dartmouth Medical School, Hanover, NH; Matt Wargo, Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT

9:20 - 9:40 AM

Non-invasive Imaging of Host Response in a Transparent Vertebrate Model of Candidemia.  Kimberly Brothers, Graduate School of Biomedical Sciences; Zachary Newman, Robert Wheeler, Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME

9:40 - 10:00 AM

Antifungal Therapies in a Neonatal Mouse Model of Disseminated Candidiasis.  Nancy Tsai, Sonia Laforce-Nesbitt, Joseph Bliss, Department of Pediatrics, Women and Infants Hospital, providence, RI; Louis Hoyer, College of Veterinary Medicine, University of Illinois, Urbana-Champaign, Urbana, IL

Workshop 1:  Evaluating INBRE Projects in the Northeast Region

Room 270, O'Hare Academic Center

Chair: 

Cheryl Ackerman, Delaware INBRE Internal Evaluator, University of Delaware, Newark, DE

8:00 - 8:05 AM

Introduction.  Cheryl Ackerman, Delaware INBRE Internal Evaluator, University of Delaware, Newark, DE

8:05 - 8:15 AM

Evaluation in Rhode Island.  Bongsup Cho, Rhode Island INBRE Program Coordinator, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI

8:15 - 8:25 AM

Evaluation in Maine.  Michael McKernan, Maine INBRE Research Training Co-Director, Mount Desert Island Biological Laboratory, Salisbury Cove, ME

8:25 - 8:35 AM

Evaluation in Delaware.  Cheryl Ackerman, Delaware INBRE Internal Evaluator, University of Delaware, Newark, DE

8:35 - 8:45 AM

Evaluation in Vermont.  Judith Van Houten, Vermont INBRE Principal Investigator, University of Vermont, Burlington, VT

8:45 - 8:55 AM

External Evaluation.  Pallavi Phartiyal, Senior Program Associate, Research Competitiveness Program, American Association for the Advancement of Sciences, Washington, DC

8:55 - 10:00 AM

Panel Discussion

Scientific Session 3:  Developmental Biology

Bazarsky Lecture Hall, O'Hare Academic Center

Chair: 

1:00 - 1:40 PM

Preeclampsia During Pregnancy – Alzheimer’s Late in Life: A Possible Regulatory Link.  Surendra Sharma, Department of Pediatrics, Women and Infants Hospital, Providence, RI

1:40 - 2:00 PM

Notch Signaling During Embryonic Development in Mice.  Tom Gridley, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

2:00 - 2:20 PM

Epigenetic Regulation in Response to Intrauterine Environment. Carmen Marsit, Department of Epidemiology and Pediatrics, Brown University and Women and Infants Hospital, Providence, RI; Carolyn Banister, Matthew Maccani, Michele Avissar-Whiting, Amanda Filberto, Cailey Bromer, Department of Pathology, Brown University, Providence, RI; Devin Koestler, Department of Biostatistics, Brown University, Providence, RI; E. Andres Houseman, Department of Biostatistics, Oregon State University, Eugene, OR; Barry Lester, James Padbury, Women and Infants Hospital, Providence, RI 

2:20 - 2:40 PM

Retinoic Acid Expands the Evolutionarily Reduced Dentition of Zebrafish.  Pawat Seritrakul, Andrea Jowry, Tenzing Lama, Calli Coffee, and William Jackman, Department of Biology, Bowdoin College, Brunswick, ME

2:40 - 3:00 PM

Prevention of Osteoarthritis by Inhibiting Hedgehog Signaling.  Lei Wei, Frank Wei, Shaowei Wang, Qian Chen, Jingming Zhou, Department of Orthopedics, Brown Medical School, Providence, RI; Xiaochun Wei, Department of Orthopedics, Shanxi Medical University, Shanxi, China

Scientific Session 4:  Cardiovascular System and Disease

Room 260, O'Hare Academic Center

Chair:

Robert Friesel, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

1:00 - 1:40 PM

Cthrc1 Controls Vascular Remodeling Through Inhibition of Inducible Nitric Oxide Synthase Expression.  Volkhard Lindner, J. Patrizia Stohn, Anne Cuttler, Qiaozeng Wang, Lucy Liaw, Ilka Pinz, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME; Rene LeClair, Department of Biology, University of New England, Biddeford, ME

1:40 - 2:00 PM

Accelerating Fracture Healing Correlates With Enhancing Angiogenesis and Mesenchymal Stem Cells in Matrilin-1 Knockout Mice.  Qian Chen, Xin Li, Fiona Zhou, Douglas Moore, Adam Robbins, Branden Fleming, Department of Orthopedics, Brown University and Rhode Island Hospital, Providence, RI

2:00 - 2:20 PM

Effect of Obesity on Cardiovascular Event Rates in Patients with Chronic Kidney Disease.  Claudine Jurkovitz, Paul Kolm, Zugui Zhang, James Bowen, Center for Outcomes Research, Christiana Care Health System, Newark, DE; Rubeen Israni, Department of Nephrology, Nephrology Associates, Newark, DE; Robert Dressler, Edward Ewen, Department of Medicine, Christiana Care Health System, Newark, DE; J. Colin Kern, Department of Computer Science, University of Delaware, Newark, DE; William Weintraub, Department of Cardiology, Christiana Care Health System, Newark, DE

2:20 - 2:40 PM

miRNAs Control Cardiac Regenerative Capacity in Zebrafish.  Viravuth Yin, Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME; Alexandra Lepilina, Kenneth Poss, Department of Cell Biology, Duke University Medical Center, Durham, NC; Kathryn Lovine, Department of Biological Sciences, Lehigh University, Bethlehem, PA

2:40 - 3:00 PM

The Transmembrane Selenoprotein SelK.  Jun Liu and Sharon Rozovsky, Department of Chemistry, University of Delaware, Newark, DE

Scientific Session 5:  Stem Cells and Regenerative Medicine

Bazarsky Lecture Hall, O'Hare Academic Center

Chair: 

8:00 - 8:40 AM

To the Last Place of Decimals: A New Biology.  Peter Quesenberry, Rhode Island Hospital and Brown University, Providence, RI

8:40 - 9:00 AM

Immunological Considerations for Stem Cell Replacement Therapies in Regenerative Medicine. Ashleigh Boyd, Roger Williams Medical Center, Providence, RI    

9:00 - 9:20 AM

Persistence of Microvesicle-Induced Gene Expression Changes in Murine Marrow Cells Using an In Vitro and In Vivo Model.  Jason Aliotta, Mandy Pereira, Ashley Amaral, Mark Dooner, Douglas Hixson, and Peter Quesenberry, Department of Medicine, Rhode Island Hospital, Providence, RI 

9:20 - 9:40 AM

Stem Cell Mechanical Biomarkers Indicate Differentiation Potential.  Eric Darling, Rafael Gonzalez-Cruz, and Vera Fonseca, Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI

9:40 - 10:00 AM

Zinc-Finger Transcription Factor Slug:  A Key Player in Stem Cell, Cancer, and Aging.  Wen-Shu Wu, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

Scientific Session 6:  Chemical Biology

Room 260, O'Hare Academic Center

Chair:

Bongsup Cho, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI

8:00 - 8:40 AM

Development and Radiochemical Applications of a Rapid Method of Bioconjugation.  Joseph Fox, Department of Chemistry, University of Delaware, Newark, DE

8:40 - 9:00 AM

Synthesis and SiRNA Binding of Cationic Polyamines.  Mindy Levine and Justin Gharavi, Department of Chemistry, University of Rhode Island, Kingston, RI

9:00 - 9:20 AM

Immunoassay Arrays for Immunoelectrochemical Detection of Oral Cancer Biomarker Proteins in Serum.  Bernard Munge, Department of Chemistry, Salve Regina University, Newport, RI

9:20 - 9:40 AM

Quantitative Phosphoproteomics Defines Novel Substrates and Functional Modules of the Aurora and Polo-like Kinases in Mitosis.  Arminja Kettenbach, Devin Schweppe, Brendan Faherty, Dov Pechenick, Alexandre Pletnev, and Scott Gerber, Department of Genetics, Dartmouth Medical School, Lebanon, NH

9:40 - 10:00 AM

Pseudomonad Volatile Metabolites: How Many, How Different, and What Are the Implications.  H. Bean, J. Zhu, and Jane Hill, Department of Immunology and Infectious Diseases, University of Vermont, Burlington, VT

Workshop 2:  North East Cyberinfrastructure Consortium (NECC)

Rooms 228 - 229, O'Hare Academic Center

Co- Chairs: 

Judith Van Houten, Vermont INBRE Principal Investigator, University of Vermont, Burlington, VT; Karl Steiner, Delaware INBRE Principal Investigator, University of Delaware, Newark, DE

8:00 - 8:05 AM

Introductory Remarks.  Judith Van Houten, Vermont INBRE Principal Investigator, University of Vermont, Burlington, VT

8:05 - 8:15 AM

Fiber Installation in Maine.  Jeff Letourneau, Executive Director, Networkmaine, University of Maine, Orono, ME

8:15 - 8:25 AM

Fiber Installation in New Hampshire.  Scott Valcourt, Director of Project Management and Consulting Services, Information Technology Department, University of New Hampshire, Durham, NH

8:25 - 8:35 AM

Fiber Installation in Rhode Island.  David Porter, Director, Media & Technology Services, University of Rhode Island, Kingston, RI

8:35 - 8:45 AM

Fiber Installation in Vermont.  Kelvin Chu, Associate Director, Vermont Genetics Network, University of Vermont, Burlington, VT

The Skate Genome Project.  Benjamin King, Staff Scientist and Biostatistician, Mount Desert Island Biological Laboratory, Salisbury Cove, ME

9:05 - 9:25 AM

Bioinformatics Collaboration and Workforce Development: Skate Genome Annotation Workshops.  Cathy Wu, Bioinformatics Director, Delaware INBRE, University of Delaware, Newark, DE

Shared Data Center in Delaware.  Karl Steiner, Delaware INBRE Principal Investigator, University of Delaware, Newark, DE

9:40 - 10:00 AM

Panel Discussion

Scientific Session 7:  Neuroscience and Behavior

Bazarsky Lecture Hall, O'Hare Academic Center

Chair: 

10:40 - 11:00 AM

Human Low Voltage-activated Calcium Channel Isoforms are Inhibited by Pyrethroids.  Steven Symington, Department of Biology and Biomedical Sciences, Salve Regina University, Newport, RI

11:00 - 11:20 AM

The Role of Central Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Signaling in Stress-Related Anxiety.  Sayamwong Hammack, Margarete Kocho-Schellenberg, Kimberley Lezak, Vincenzo Piraino, Donna Toufexis, Department of Psychology, University of Vermont, Burlington, VT; Kerry Kessler, Department of Psychiatry and Behavioral Sciences, Emory University of Medicine, Atlanta, GA; Carolyn Roman, Department of Anatomy and Neurobiology, University of Vermont School of Medicine, Burlington, VT; Karen Brass, Victor May, Department of Anatomy and Neurobiology, University of Vermont School of Medicine, Burlington, VT

11:20 - 11:40 AM

Development of an Animal Model of Non-Suicidal Self-Injury (NSSI).  Christopher Bloom, Brittany Blumenthal, Nicole Elsinger, Liz Sokolowski, Department of Psychology; Ryan Bastings, Department of Biology, Providence College, Providence, RI

11:40 - 12:00 PM

Altering Trajectories Into Pathology With Dietary Choline Supplementation Early in Life.  Melissa Glenn, Arielle Saporta, Derek Wise, Samantha Gillies, Department of Psychology; Nora McCall, Angeliza D’Aiello, Department of Biology, Colby College, Waterville, ME

Scientific Session 8:  Infectious Disease

Room 260, O'Hare Academic Center

Chair:

Walter Atwood, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

10:40 - 11:00 AM

Chemically Interrogating Clostridium Difficile Glucosylating Toxin Activation.  Aimee Shen, Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT; Patrick Lupardus, K. Christopher Garcia, Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA; Aarion Puri, Department of Chemical and Systems Biology, Stanford University, Stanford, CA; Malte Gersch, Department of Microbiology and, Technische Universitat, Munhen, Garching, Germany; Victoria Albrow, Matthew Bogyo, Department of Pathology, Stanford University, Stanford , CA

11:00 - 11:20 AM

Choline Catabolism is Important for Pseudomonas aeruginosa Virulence in the Lung.  Matthew Wargo, Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT

11:20 - 11:40 AM

Metal Dependent Regulation of Actinomyces naesslundii Siderophore Production and Biofilm Formation. Lori Bergeron, Department of Biology, New England College, Henniker, NH

11:40 - 12:00 PM

The Role of Calcium Chanel Genes in the Generation of Pulsatile Calcium in Polarized Hyphal Tip Growth: Leveraging IDeA Core Facility Support to Build Your Research Program.  Kirk Czymmek, Hye-Seon Kim, Department of Biological Sciences, University of Delaware, Newark, DE; Seogchan Kang, Department of Plant Pathology, Pennsylvania State University, University Park, PA

Workshop 3:  Sustaining Crucial Core Resources and Enhancing the Technological Capabilities at IDeA-Funded Institutions

Rooms 228 - 229, O'Hare Academic Center

Chair: 

Timothy Hunter, Director, Microarray Facility, Vermont Genetics Network at the University of Vermont, Burlington, VT

10:40 - 11:00 AM

Challenges and Opportunities for the IDeA-funded Cores.  Katia Sol-Church, Co-Director, Delaware INBRE Central Research Instrumentation Core, Nemours Center for Pediatric Research, Alfred I. DuPont Hospital for Children, Wilmington, DE

11:00 - 11:20 AM

Post COBRE and INBRE Funding: Best Practices to Sustain Critical Resources.  Timothy Hunter, Director, Microarray Facility, Vermont Genetics Network at the University of Vermont, Burlington, VT

11:20 - 11:40 AM

Regional Sharing. Stephen Bobin, Administrative Coordinator, Shared Resources, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH

11:40 - 12:00 PM

Panel Discussion