The Applied Biosystems Procise® Protein Sequencing System automates the amino acid sequence of proteins or peptides by the Edman degradation, a chemical process that removes and analyzes amino acid residues from protein and peptide chains of various types and length. The instrument delivers volumes of reagents to a cartridge where the polypeptide is applied to a glass-fiber filter, which has been previously treated with BioBrene or a PVDF membrane. At each cycle the PTH-amino acid is transferred to the HPLC for analysis and quantification. The Protein sequencing system is composed of four integrated modules: The protein Sequencer, Model 140C Microgradient LC System, PE 200 UV/VIS Detector and SequencePro™ Software.

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