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RI-INBRE Research (2004 -
2009)
Faculty Development
Projects
The Role for the
Aryl Hydrocarbon Receptor in Netrin-1 Signaling (2005 -
2007) Investigator: Joseph Bartoe, Providence College Mentor: Julie Kauer, Brown University
E. Hystolica EhADH2
Enzyme as Anti-Amoebic Target (2004 - 2007) Investigator:
Avelina Espinosa, Roger Williams University Mentor: David
Nelson, University of Rhode Island
Methyl Tertiary-Butyl Ether Causes
Testicular Injury (2004 - 2005) Investigator: Eric Hall, Rhode Island
College Mentor: Kim Boekelheide, Brown
University
Growth Control in
the Testis and Molecular Mechanisms of Testicular Homeostasis in
Toxicant-Induced Testicular Injury (2004 - 2007) Investigator: Mary
Hixon, Brown University Mentor: Kim
Boekelheide, Brown University
Mechanistic Studies
of Protein Tyrosine Kinase Activation by Arsenite (2004 - 2005) Investigator:
Keykavous Parang, University of Rhode Island Mentors: Bingfang
Yan, University of Rhode Island, Bongsup Cho, University of Rhode
Island, & Zahir Shaikh, University of Rhode Island
The Effect of Molecular Toxins on Protein
Phosphates 1 Targeting (2007-2008)
Investigator: Wolfgang Peti, Brown
University
Mentor: Edward Hawrot, Brown
University
Mechanisms of Bacterial Mediation of
Dinoflagellate Toxigenesis (2004 - 2004) Investigator: David Rowley, University
of Rhode Island Mentor: Yuzuru Shimizu, University of
Rhode Island
Molecular and
Biochemical Characterization of a Secreted Lipase in Leishmania
(2004 - 2007) Investigator:
Alison Shakarian, Salve Regina University Mentor: David
Nelson, University of Rhode Island
Mechanism of C-SRC Activation by
Oxidative Stress (2004 - 2005) Investigator: Gongqin Sun, University of
Rhode Island Mentor: Bingfang Yan, University of
Rhode Island
Role of the Antizyme Family During
Xenopus Development (2004 - 2005) Investigator: Charles Toth, Providence
College Mentor: Kim Boekelheide, Brown
University
Cell Signaling Leading to UV-Induced Cell
Injury (2004 - 2005) Investigator: Yinsheng Wan, Providence
College Mentor: Bingfang Yan, University of
Rhode Island
Heavy Metal-Induced
Alteration of Cardiovascular Development (2004 - 2007) Investigator:
Kerri Warren, Roger Williams University Mentors: Robert
Rodgers, University of Rhode Island & Zahir Shaikh, University of
Rhode Island
Undergraduate
Student Training
Projects
Methyl Tertiary-Butyl Ether Causes Testicular Injury (2005-2008)
Investigator: Eric Hall, Rhode Island College
Role of the Antizyme Family During Xenopus
Development (2005-2008)
Investigator: Charles Toth, Providence
College
Heavy Metal-Induced Alteration of
Cardiovascular Development (2007-2008)
Investigator: Kerri Warren, Roger Williams University
Pilot Projects
Exploring Nucleocytoplasmic Shuttling of
Metabolic Enzymes (2006 - 2007) Investigator: Alexander Brodsky, Brown
University Mentor: Stephen L. Helfand, Brown
University
Relating Biomembrane Disruption to the
Potential Toxicity of Synthetic Inorganic Nanoparticles (2007 - 2008)
Investigator: Geoffrey Bothun, University of Rhode Island Mentor:
Arijit Bose, University of Rhode Island
Total Synthesis of UCS1025A and
Derivatives Thereof for Use as Anti-Telomerase Agents (2005 - 2006) Investigator: Brenton DeBoef, University
of Rhode Island Mentor: William Euler, University of
Rhode Island
Transcriptional Regulation of Bile Salt
Export Pump (2006 - 2007) Investigator: Ruitang Deng, University
of Rhode Island Mentor: Bingfang Yan, University of
Rhode Island
Mutagenesis and Toxicity of Peroxynitrite-Induced
DNA Lesions in Human Cells (2007 - 2008) Investigator: Sarah
Delaney, Brown University Mentor: Anatoly Zhitkovich, Brown
University
Transcriptional Regulation of Bile Salt
Export Pump by Endobiotics and Xenobiotics (2005 - 2006) Investigator: Ruitang Deng, University
of Rhode Island Mentor: Bingfang Yan, University of
Rhode Island
Toxicological Significance of Bile Export
Pump (2004 - 2006) Investigator: Ruitang Deng, University of
Rhode Island Mentor: Bingfang Yan, University of
Rhode Island
Dissecting Regulation of Intracellular
Vesicle Trafficking in a Tick Salivary Gland Model (2006 - 2007) Investigator: Shahid Karim, University
of Rhode Island Mentors: Thomas N. Mather, University of
Rhode Island & Gary Wessel, Brown University
Estrogen Sulfotransferase and Estradiol
Homeostasis in Mammary Epithelial Cells (2005 - 2006) Investigator: Roberta King, University
of Rhode Island Mentors: Bongsup Cho, University of Rhode
Island & Bingfang Yan, University of Rhode Island
Estrogen Sulfotransferase Inhibition and
Breast Cancer (2004 - 2005) Investigator: Roberta King, University
of Rhode Island Mentors: Bongsup Cho, University of
Rhode Island & Bingfang Yan, University of Rhode Island
The
Effects of Early Embryonic Exposure to PCBs on the Developing Nervous
System (2007 - 2008) Investigator: Jill Kreiling, Brown University Mentor:
Surendra Sharma, Brown University
Development of a New Class of Antibiotics
(2005 - 2006) Investigator: Thilo Lange, Brown University Mentor: Susan Gerbi, Brown University
Evaluating Alpha Toxin and Biofilm
Formation in Staphylococcus Aureus Through the Accessory Gene
Regulator Operon (agr) (2006 - 2007) Investigator: Kerry LaPlante, University
of Rhode Island Mentor: David Rowley, University of
Rhode Island
Antimicrobial Agents that Inhibit
Alpha-Toxin, Prevent Biofilm Formation in Staphylococcus aureus
(2005 - 2006) Investigator: Kerry LaPlante, University
of Rhode Island Mentor: David Rowley, University of
Rhode Island
Profile of miRNA Expression Alterations by
Endocrine Disrupting Toxicants (2007 - 2008)
Investigator: Carmen Marsit, Brown
University
Mentor: Kim Boekelheide, Brown University
Surface Hsc/OC.10 Confers a Growth and Survival Advantage to Oval
Cells, Cholangiocytes and Hepatocellular Carcinomas (2007 - 2008)
Investigator: David Mills, Rhode
Island Hospital
Mentor: Douglas Hixson, Brown University
The Effects of Environmental Oxidants on
HePTP Structure and MAP Kinase Interaction (2007 - 2008)
Investigator: Rebecca Page, Brown
University
Mentor: Kristi Wharton, Brown University
Design of Anticancer Cytotoxins (2004 - 2005) Investigator: Yana K. Reshetnyak,
University of Rhode Island Mentor: Clinton Chichester, University
of Rhode Island
Pilot Undergraduate Student Training
Projects
Promoting Apoptosis Using Small Molecule
Inhibitors of Bcl-xL (2006 - 2007) Investigator: Jay Pike, Providence
College
Synthesis, Analysis, Toxicity Screening and
Computational Chemistry of Arylphosphonium Salts Conjugated with Lipids
and Polypeptides (2006 - 2008) Investigator: John C. Williams, Jr.,
Rhode Island College
RI-BRIN Research
(2001-2004)
Faculty Development
Projects
Pharmacokinetics and
Pharmacodynamics of Immunosuppressive Agents (2002 - 2004) Investigator:
Fatemeh Aklaghi, University of Rhode Island Mentor: Bingfang
Yan, University of Rhode Island
Neural Architecture
and the Mechanisms for Learning and Memory Storage (2001 - 2004) Investigator: Brian
Blais, Bryant College Mentor: Nasser H.
Zawia, University of Rhode Island
Developing a
Tailored, Mismatched Intervention for Increasing the Physical
Activity Behavior of Sedentary Adults Subcore (2001 - 2004) Investigator:
Bryan Blissmer, University of Rhode Island Mentor: Wayne F.
Velicer, University of Rhode Island
The Effects of
Endocrine Disruptors on Complex Behavior Patterns (2001 - 2003) Investigator: Ethan
Clotfelter, Providence College Mentor: Zahir
Shaikh, University of Rhode Island
Localization of SP
Family of Transcription Factors in the Developing Brain (2001 -2004) Investigator: Suzanne
Conklin, Rhode Island College Mentor: Nasser H.
Zawia, University of Rhode Island
Acrylamide and
Intermediate Filaments in Mouse Sertoli Cells (2001 - 2004) Investigator: Eric
Hall, Rhode Island College Mentor: Kim
Boekelheide, Brown University
A Mechanism for
Phthalate-Induced Testicular Injury: Cadherin Disruption (2001 -
2003) Investigator: Kamin
Johnson, Brown University Mentor: Kim
Boekelheide, Brown University
Co-Variation in
Alcohol Abuse and Smoking in Adolescents and Their Parents Subcore
(2001 - 2004) Investigator: Randi
Kim, Rhode Island College Mentor: James Prochaska, University of Rhode Island
Sulfotransferase
Inhibitors: Chemoprevention and Drug Interactions (2001 - 2004) Investigator:
Roberta King, University of Rhode Island Mentor: Bongsup Cho,
University of Rhode Island
Mental Health
Benefits from Cancer Prevention (2001 - 2004) Investigator: Daniel
Koonce, University of Rhode Island Mentor: Wayne F.
Velicer, University of Rhode Island
A 3-D Model of the
Transport and Diffusion of Chemotherapy Drugs into the Brain for
Tumor Volume Reduction (2002 - 2004) Investigator: Donna M.
Meyer, University of Rhode Island Mentor: Ying Sun,
University of Rhode Island
Changes in High Risk
Sex and Cigarette Smoking as Preludes to Immunization for Hepatitis
(2001 - 2004) Investigator: Mary
O'Keeffe, Providence College Mentor: James
Prochaska, University of Rhode Island
Metal Contamination
and Human Health (2001 - 2004) Investigator: Steven
O'Shea, Roger Williams University Mentor: Zahir Shaikh,
University of Rhode Island
Mechanisms of
Diolepoxide-DNA Interaction (2001 - 2004) Investigator:
Kenneth R. Overly, Providence College Mentor: Bongsup
Cho, University of Rhode Island
Biososteres of
Tyrosine Phosphate as Inhibitors of the SH2 Domain of Tyrosine
Kinases (2001 - 2004) Investigator: Keykavous
Parang, University of Rhode Island Mentor: Bingfang
Yan, University of Rhode Island
Drugs from the
Sea: Especially from Marine Microbes (2001 - 2004) Investigator: David
Rowley, University of Rhode Island Mentor: Yuzuru
Shimizu, University of Rhode Island
The Role of the 26S
Proteasome Component Rpn6 in Directing Ubiquitinated Substrates to
the Proteasome (2002 - 2004) Investigator:
Jeffrey D. Singer, Brown University Mentor: John Sedivy,
Brown University
Metal Cations in
PTK Catalysts and Inhibitor Design (2001 - 2004) Investigator: Gongqin
Sun, University of Rhode Island Mentor: Bingfang
Yan, University of Rhode Island
Targeting of
Proteins to the 26S Proteasome: Determination of Antizyme Function
(2001 - 2004) Investigator:
Charles Toth, Providence College Mentor: Bingfang
Yan, University of Rhode Island
Regional
Electrophysiological Effects of Heterogeneous Cardiac Deformation
(2002 - 2004) Investigator:
Frederick J. Vetter, University of Rhode Island Mentors: Ying Sun,
University of Rhode Island & Robert L. Rodgers, University of Rhode
Island
Herb-Mediated Blockade
on UV Signaling (2001 - 2004) Investigator: Yinsheng
Wan, Providence College Mentor: Bingfang
Yan, University of Rhode Island
Mathematical
Modeling of Cardiovascular Mechanics and Metabolism (2001 - 2004) Investigator: Li Wu,
University of Rhode Island Mentors: Ying Sun,
University of Rhode Island & Robert L. Rodgers, University of Rhode
Island
Pilot Projects
Distribution and
Metabolism of Immunosuppressive Agents (2001 - 2002) Investigator: Fatemeh
Akhlaghi, University of Rhode Island Mentor: Bingfang
Yan, University of Rhode Island
Genetic
Characterization of the Different Histological Types of Malignancy
in Colorectal Cancer (2003 - 2004) Investigator:
Elisaabeth Arévalo, Providence College Mentor: Bongsup
Cho, University of Rhode Island
Fluorinated
Membranes - A Model for Raft Formation (2001 - 2002) Investigator: Amit
Basu, Brown University Mentor: Matthew
Zimmit, Brown University
Electrocardiographic and Hemodynamic Effects of a Dietary Weight
Loss Supplement Containing Ephedrine and Caffeine (2002 - 2003) Investigator:
Michael Caron, University of Rhode Island Mentor: Robert
Rodgers, University of Rhode Island
Phase Space Warping
Based Diagnosis of Long-Term Changes in Human Coordination (2002 - 2003) Investigator: David
Chelidze, University of Rhode Island Mentor: Arun Shukla,
University of Rhode Island
Metal Interactions in
Csk Protein-Tyrosine Kinase (2003 - 2004) Investigator:
Glenisson de Olivéira, Rhode Island College Mentor: Bingfang Yan,
University of Rhode Island
Novel Antimicrobial
Peptides of Marine Origin: Recombinant Expression and Processing by
Proteolytic Enzymes (2003 - 2004) Investigator: Marta
Gómez-Chiarri, University of Rhode Island Mentor: Bingfang Yan,
University of Rhode Island
Transgenic
Cis-Regulatory Analysis of a Simple Two-Gene Cluster (2002 - 2003) Investigator: Steve
Irvine, University of Rhode Island Mentor: Nasser Zawia,
University of Rhode Island
Transgenic
Cis-Regulatory Analysis of Development Genes in Ascidians (2003 - 2004) Investigator: Steve
Irvine, Brown University Mentor: Nasser Zawia,
University of Rhode Island
Stochastic Resonance in
a Subexcitable System (2001 - 2002) Investigator: Sandor
Kadar, Salve Regina University Mentor: Bongsup Cho,
University of Rhode Island
Spatiotemporal
Stochastic Resonance in a Subexcitable Chemical System (2003 - 2004) Investigator: Sandor
Kadar, Salve Regina University Mentor: Bongsup Cho,
University of Rhode Island
Design of Sensors for
the Detection of Organohalides and Organophophates Using Time-Resolved
Fluorescence (2002 - 2003) Investigator: Jaycoda
Major, University of Rhode Island Mentor: William Euler,
University of Rhode Island
Separation of Wear
Debris in Total Joint Replacements Using Bio-Ferrography (2001 - 2002) Investigator: Donna
Meyer, University of Rhode Island Mentor: Ying Sun,
University of Rhode Island
Latent Growth Curve
Modeling of Health Behavior Changes Among Adolescents (2002 - 2003) Investigator: Nansook
Park, University of Rhode Island Mentor: Wayne Velicer,
University of Rhode Island
Mechanisms of Emotional
Modulation in Human Visual Cortex (2003 - 2004) Investigator: Luiz
Pessoa, Brown University Mentor: Sheila
Blumstein, Brown University
Evaluation of Graded
Materials for Use in Total Joint Replacement (2002 - 2003) Investigator:
Carl-Ernst Rousseau, University of Rhode Island Mentor: Arun Shukla,
University of Rhode Island
Evaluation of Contact
Stresses in Graded Materials Used in Total Joint Replacement (2003 -
2004) Investigator:
Carl-Ernst Rousseau, University of Rhode Island Mentor: Arun Shukla,
University of Rhode Island
Manufacturing Processes
for Biomedical Implants Using Laser Engineered Net Shaping (LENS)
Technology (2003 - 2004) Investigator: Valerie
Maier Speredelozzi, University of Rhode Island Mentor: Arun Shukla,
University of Rhode Island
Brain Structure and
Activation in Children Born Preterm (2002 - 2004) Investigator: Mary
Sullivan, University of Rhode Island Mentor: Margaret
McGrath, University of Rhode Island
A Quantitative
Description of the Cardiac Papillary Muscle Insertion (2001 - 2002) Investigator: Fred
Vetter, University of Rhode Island Mentors: Robert
Rodgers, University of Rhode Island & Ying Sun, University of Rhode
Island
Evaluation of Deer Tick
Eggs Antigens as an Anti-Tick Vaccine (2001 - 2002) Investigator: Ulysses
Whitworth, University of Rhode Island Mentor: Nasser Zawia,
University of Rhode Island
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