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Faculty
Development Projects
The Role of Alternative Splicing of Ufd2a in Differentiation (2006 -
Present)
Investigator:
Sarah
Spinette, Rhode Island College
Mentor: Kenneth
Walsh, Boston University School of Medicine
Abstract:
Determining the molecular mechanisms involved in the differentiation
of post-mitotic cells such as striated muscle cells and neurons,
will be crucial for understanding and controlling the way in which
tissue regeneration occurs and extremely valuable for the use of
stem cell therapies.
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Undergraduate
Student Training Projects
Genetic and Molecular Analysis of Aging and Apoptosis in the Yeast,
Saccharomyces (2008 - Present)
Investigator:
Nicanor Austriaco, Providence College
Mentor: Brian Kennedy,
University of Washington School of Medicine
Abstract:
Cellular aging and apoptosis are two cellular processes that have
been implicated in human disease. For instance, it is now clear that
both are potent anti-cancer mechanisms.
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E. Hystolica EhADH2
Enzyme as Anti-Amoebic Target (2007 - Present)
Investigator:
Avelina Espinosa,
Roger
Williams
University
Abstract:
The intestinal protozoan Entamoeba histolytica is a major cause of
morbidity and mortality worldwide, causing fifty million cases of
diarrhea and one hundred thousand deaths per year.
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Molecular and
Biochemical Characterization of a Secreted Lipase in Leishmania (2007 -
Present)
Investigator:
Alison Shakarian,
Salve
Regina
University
Abstract:
This subproject is designed to contribute to the understanding of
mechanisms of Leishmania survival, growth and development.
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Pilot Projects
Dissecting the Gene
Regulatory Network for Epidermis (2008 - Present)
Investigator:
Steven Irvine,
University of Rhode Island
Mentor:
David Nelson, University of Rhode Island
Abstract:
The epidermis, being the interface between an animal and its
environment, and the largest organ, has great importance in human
health. Developmental defects of the epidermis, and its associated
structures, such as teeth and hair, may be due in part to disruptions of
epidermal gene regulatory pathways.
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Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin
(2008 - Present)
Investigator:
Becky Sartini, University of Rhode Island
Mentor:
Gary Wessel, Brown University
Abstract:
Male infertility accounts for one third of the couples that seek
treatment for failure to conceive. Recent research has shown that
aberrant regulation of gene expression during spermatogenesis causes
decreased sperm function.
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