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Collaborative Projects
Distribution and
Regulation of the Amyloid Procursor Protein of Alzheimer's (AD) (2011 - Present)
Investigator:
Joseph DeGiorgis,
Providence College
Collaborator/Mentor:
John Marshall, Brown University
Abstract:
Alzheimer's disease (AD)
afflicts an estimated 26.6 million individuals worldwide, and the
prevalence is predicted to increase to 100 million by 2050 at an
estimated cost of 20 trillion dollars over the next 40 years to the US
alone. Many familial forms of AD are caused by mutations in the Amyloid
Precursor Protein.
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Bacterial Glycome as
Antibacterial Targets (2011 - Present)
Investigator:
Christopher Reid, Bryant University
Co-Investigator:
Kirsten Hokeness, Bryant University
Collaborator/Mentor:
Amit Basu, Brown University
Abstract:
The manifestation of
multidrug resistance in bacteria over the past several decades has
resulted in one of the foremost challenges in the management of
infectious diseases. The question is, how do we address this growing
problem?
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Student Training Projects
Examination of UFD2a/UBE4B Function During Myogenesis In Vivo (2012 -
Present)
Investigator:
Sarah
Spinette, Rhode Island College
Mentor:
David Goldhamer, University of Connecticut
Abstract:
Research over the
past decade has succeeded in mapping the intricate network of
transcriptional regulators that are critical to both the
specification of the myogenic lineage and the process of de novo
myongenesis in vivo, yet there are still no cures for the large and
genetically heterogeneous group of muscle diseases.
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The Physiological Role of Plant Phenolics in Plant and Mammalian Cell
Growth (2012 -
Present)
Investigator:
John-David Swanson, Salve Regina University
Mentor:
Marie Chow, University of Arkansas
Abstract:
Plant secondary
metabolites provided many leads for new therapeutics that are
currently on the market. However their mechanism of action is
often not understood in either plants or animals. Our
preliminary data show that, in Rubus, phenolics (a class of
secondary metabolites), produced in the head structure of the
glandular trichomes, are transported to cellular nuclei in the
underlying stalk tissue.
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