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Collaborative Projects
Distribution and
Regulation of the Amyloid Procursor Protein of Alzheimer's (AD) (2011 - Present)
Investigator:
Joseph DeGiorgis,
Providence College
Collaborator/Mentor:
Thomas Reese, National Institutes of Health
Abstract:
Alzheimer's disease (AD)
afflicts an estimated 26.6 million individuals worldwide, and the
prevalence is predicted to increase to 100 million by 2050 at an
estimated cost of 20 trillion dollars over the next 40 years to the US
alone. Many familial forms of AD are caused by mutations in the Amyloid
Precursor Protein.
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Bacterial Glycome as
Antibacterial Targets (2011 - Present)
Investigator:
Christopher Reid, Bryant University
Co-Investigator:
Kirsten Hokeness, Bryant University
Collaborator/Mentor:
Amit Basu, Brown University
Abstract:
The manifestation of
multidrug resistance in bacteria over the past several decades has
resulted in one of the foremost challenges in the management of
infectious diseases. The question is, how do we address this growing
problem?
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Student Training Projects
Examination of UFD2a/UBE4B Function During Myogenesis In Vivo (2012 -
Present)
Investigator:
Sarah
Spinette, Rhode Island College Mentor:
David Goldhamer, University of Connecticut
Abstract:
Research over the
past decade has succeeded in mapping the intricate network of
transcriptional regulators that are critical to both the
specification of the myogenic lineage and the process of de novo
myogenesis in vivo, yet there are still no cures for the large and
genetically heterogeneous group of muscle diseases.
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The Physiological Role of Plant Phenolics in Plant and Mammalian Cell
Growth (2012 -
Present)
Investigator:
JD
Swanson, Salve Regina University Mentor:
Marie Chow,University of Arkansas
Abstract:
RPlant secondary
metabolites provided many leads for new therapeutics that are
currently on hand. However, their mechanism of action is often
not understood in either plants or animals. Our preliminary
data show that, in Rubus, phenolics (a class of secondary
metabolites), produced in the head structure of the glandular
trichomes, are transported to cellular nuclei in the underlying
stalk tissue.
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Student Training
Pilot Projects
Genetic Characterization of Bax Inhibitor (BXI1) Function in the Budding Yeast,
Saccharomyces cerevisiae
Programmed Cell Death (2012 - Present)
Investigator:
Nicanor Austriaco, Providence College
Abstract:
Apoptosis is both an important physiological process and
a significant anti-tumor defense mechanism in multicellular organisms.
Cells that bypass apoptosis in response to oncogenic stimuli can
undergo malignant transformation.
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Experimental Test of the Myogenic Code Hypothesis (2012 -
Present)
Investigator:
Thomas
Meedel, Rhode Island College
Abstract:
The objective of this project is to
determine whether the alanine-threonine (Ala-Thr) dipeptide found in
all Myogenic Regulatory Factor (MRF) genes and known as the "Myogenic
Code", is essential for their activity. MRFs exist in animals
ranging from worms to humans, and they are typically active only in
muscle or muscle precursor cells where they play key roles in
myogenesis.
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Identification of Differentially Expressed Genes
Among Leishmania Species (2012 -
Present)
Investigator:
Alison
Shakarian, Salve Regina University
Abstract:
The long term goal of this project is to
identify and characterize differentially expressed genes in
Leishmania that may be used as potential novel targets for the
development of new drug therapies for the treatment of leishmaiasis.
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