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Faculty
Development Projects
Genome Stability through Bloom Syndrome Helicase and Rad51 Complex
Formation (2005 - Present)
Investigator:
Karen Almeida, Rhode Island College
Mentor: Robert
Sobol, University of Pittsburgh
Abstract:
One of the hallmark features of tumor cells is a highly unstable genome.
Bloom syndrome (BS), an autosomal recessive disorder that results from a
mutation of the BLM gene, exhibits extraordinarily high levels of sister
chromatid exchange (SCE) events, a marker of genomic instability.
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Genetic and Molecular Analysis of Aging and Apoptosis in the Yeast,
Saccharomyces (2005 - Present)
Investigator:
Nicanor Austriaco, Providence College
Mentor: Brian Kennedy,
University of Washington School of Medicine
Abstract:
Cellular aging and apoptosis are two cellular processes that have
been implicated in human disease. For instance, it is now clear that
both are potent anti-cancer mechanisms.
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The Role of Alternative Splicing of Ufd2a in Differentiation (2006 -
Present)
Investigator:
Sarah
Spinette, Rhode Island College
Mentor: Kenneth
Walsh, Boston University School of Medicine
Abstract:
Determining the molecular mechanisms involved in the differentiation
of post-mitotic cells such as striated muscle cells and neurons,
will be crucial for understanding and controlling the way in which
tissue regeneration occurs and extremely valuable for the use of
stem cell therapies.
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