Mechanisms of CpG-ODN's Protection against UV-induced Cell Death (2009 - Present)

Investigator:  Yinsheng Wan, Providence College

Mentor:  John Marshall, Brown University 

Publications

2008 - 2009

Song, X., Xu, A., Pan, W., Wallin, B., Kivlin, R., Lu, S., Cao, C., Bi, Z., Wan, Y. 2008. Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. Int. J. Mol. Med., 22, 9-16.

Song, X., Xu, A., Pan, W., Wallin, B., Kivlin, R., Lu, S., Cao, C., Bi, Z., Wan, Y. 2008. Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. Int. J. Mol. Med., 22, 229-236.

Cao, C., Lu, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Chu, W., Guan, K., Wan, Y. 2008. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J. Biol. Chem., 283, 28897-28908.

Cao, C., Lu, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Wang, W., Song, X., Chu, W., Kouttab, N., Xu, A., Wan, Y. 2008. SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J. Cell. Mol. Med., Epub 2008 Aug 4.

Cao, C., Lu, S., Jiang, Q., Wang, W., Song, X., Kivlin, R., Wallin, B., Bagdasarian, A., Tamakloe, T., Chu, W., Marshall, J., Kouttab, N., Xu, A., Wan, Y. 2008. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cell Signal, 20, 1830-1838.

Cao, C., Lu, S., Sowa, A., Kivlin, R., Amaral, A., Chu, W., Yang, H., Di, W., Wan, Y. 2008. Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. Cancer Lett., 266, 249-262.

Cao, C., Wan, S., Jiang, Q., Amaral, A., Lu, S., Hu, G., Bi, Z., Kouttab, N., Chu, W., Wan, Y. 2008. All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J. Cell Physiol., 215, 506-516.

Chen, W., Kang, J., Xia, J., Li, Y., Yang, B., Chen, B., Sun, W., Song, X., Xiang, W., Wang, X., Wang, F., Wan, Y., Bi, Z. 2008. p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. Int. J. Mol. Med., 21, 645-653.

Ji, C., Cao, C., Lu, S., Kivlin, R., Amaral, A., Kouttab, N., Yang, H., Chu, W., Bi, Z., Di, W., Wan, Y. 2008. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother. Pharmacol., 62, 857-865.

Jiang, Q., Cao, C., Zhou, C., Song, X., Healey, S., Kouttab, N., Chu, W., Xu, A., Bi, Z., Wan, Y. 2008. Quercetin attenuates UV- and H2O2-induced decrease of collagen type I in cultured human lens epithelial cells. J. Ocul. Pharmacol. Ther., 24, 164-174.

Kang, J., Chen, W., Xia, J., Li, Y., Yang, B., Chen, B., Sun, W., Song, X., Xiang, W., Wang, X., Wang, F., Bi, Z., Wan, Y. 2008. Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathways. Int. J. Mol. Med., 21, 777-784.

Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., Wan, Y. 2008. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol. Rep., 20, 1553-1559. 

Shi, J., Wan, Y., Di, W. 2008. Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells. Oncol. Rep., 20, 803-807.

Zhao, D., Li, Y., Wang, P., Zhou, M., Guan, C., Wei, X., Wan, Y., Xu, A. 2008. Melagenine modulates proliferation and differentiation of melanoblasts. Int. J. Mol. Med., 22, 193-197.

2007 - 2008

Cao, C., Healey, S., Amaral, A., Lee-Couture, A., Wan, S., Kouttab, N., Chu, W.M., Wan, Y.S. 2007. ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage. J. Cell Physiol. 212, 252-263.

2006 - 2007

Cao, C., Sun, Y., Healey, S., Bi, Z., Hu, G., Wan, S., Kouttab, N., Chu, W., Wan, Y. 2006. EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. Biochem. J., 400, 225-234.

Jiang, Q., Bi, Z., Chu, W., Kouttab, N., Wan, Y. 2006. UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells. Int. J. Mol. Med., 18, 381-387.

Jiang, Q., Zhou, C., Bi, Z., Wan, Y. 2006. EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells. J. Ocul. Pharmacol. Ther., 22, 93-102.

Li, Y., Yan, B., Wan, Y. 2006. UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. Int. J. Mol. Med., 18, 713-719.

Luo, J., Wan, Y. 2006. Tightly regulated distribution of family members of proteins is related to social property in the open body system. Int. Mol. Med., 17, 411-418.

Qiu, L., Zhou, C., Sun, Y., Di, W., Scheffler, E., Healey, S., Kouttab, N., Chu, W., Wan, Y. 2006. Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation. Int. J. Oncol., 29, 1003-11.

Qiu, L., Zhou, C., Sun, Y., Di, W., Scheffler, E., Healey, S., Wanebo, H., Kouttab, N., Chu, W., Wan, Y. 2006. Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. Oncol. Rep., 16, 907-13.

Zhou, C., Qiu, L., Sun, Y., Healey, S., Wanebo, H., Kouttab, N., Di, W., Yan, B., Wan, Y. 2006. Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. Int J Oncol., 29, 269-278.

2005 - 2006

Hokeness, K., Qiu, L.H., Vezeridis, M., Yan, B.F., Mehta, S., Wan, Y.S. 2005. IFN-y enhances Paclitaxel-induced apoptosis that is modulated by activation of caspase 8 and 3 with a concomitant down regulation of the AKT survival pathway in cultured human keratinocytes. Oncol. Report, 13, 965-969.

Qiu, L., Di, W., Jiang, Q., Scheffler, E., Derby, S., Yang, J., Kouttab, N., Wanebo, H., Yan, B., Wan, Y.S. 2005.Targeted inhibition of transient activation of EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. Int. J. Oncol., 27, 1441-1448.

Qiu, L., Qun, W., Di, W., Jiang, Q., Schefeller, E., Derby, S., Wanebo, H., Yan, B., Wan, Y.S. 2005. Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. In.t J. Oncol., 27, 823-830.

Wang, X.Y., Bi, Z.G., Chu, W.M., Wan, Y.S. 2005. IL-1 receptor antagonist attenuates MAP kinase/AP-1 activation and MMP1 expression in UVA-irradiated human fibroblasts induced by culture medium from UVB-irradiated human skin keratinocytes. Int. J. Mol. Med.,16, 1117-1124.

Xia, J.P., Song, X.Z., Bi, Z.G., Chu, W.M., Wan, Y.S. 2005. UV-induced NFkB activation and expression of IL-6 is attenuated by(-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro. Int. J. Mol. Med., 16, 943-950.

2004 - 2005

Luo, J.M., Wan, Y., Wang, G.R., Floros, J., Zhou, H.H. 2004. Regularity of distribution of immunoreactive pulmonary surfactant protein A in rat tissues. Int. J. Mol. Med., 14, 341-352.

Wang, Q., Turlington, A., Heo, S., Blanco, A., Yan, B., Wan, Y., 2005. Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int. J. Mol. Med., 15, 633-640

2003 - 2004

Zhang QS, Bratton GR, Agarwal RK, Calise D, Kugel G, Wan YS, Kumar AM 2003. Lead-induced cell signaling cascades in GT1-7 cells. Brain Research Bulletin, 61, 207-17.