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DNA Damage and Biological Consequences
Aromatic amines are among the most notorious environmental chemicals that are implicated in the etiology of human cancers. Adduct formation has been confirmed in human tissues and is believed to induce cancer initiation. Hence it is imperative to elucidate how these lesions are repaired and replicated in vivo. The key molecular players such as adduct structures and proteins producing adverse outcomes must be characterized and understood in order to devise prevention and risk assessment strategies. We hypothesize that adduct-induced conformational change is important for repair efficiency and fidelity of replication. We will use various biophysical techniques to investigate structure function relationships of DNA-adducts in simulated cellular environments.
 News & Events

RI-INBRE Newsletter Fall 2009

RI-INBRE Newsletter Fall 2009

Grant Workshop PowerPoint Presentations & Handouts

Balancing Teaching and Research at PUIs

Components of a Successful AREA (R15) Grant

NSF-RUI Program: Strategies and Tips for Success

Handouts

Important Dates

RI-INBRE Calendar

12/3//09 - Shahram Khademi, Ph.D, University of Iowa - "The structure and mechanism of ammonia channels"

12/4/09 - 4th Annual BioNES Meeting, Roger Williams University, Bristol, RI

1/29/10 - RI-INBRE Research Fellows Meeting & Faculty Retreat, Providence College, Providence, RI

3/1/10 - Application Deadline for the 2010 Summer Undergraduate Research Fellowships

6/16/10 - 6/18/10 National IDeA Symposium of Biomedical Research Excellence, Bethesda, MD

 Supported by grant #  P20RR016457 from:
Contact Info
Contact RI INBRE:  
University of Rhode Island
Fogarty Hall		 | 41 Lower College Rd | Kingston, RI 02881
Phone: (401) 874-9288 | Fax: (401) 874-2646 | E-mail: riinbre@etal.uri.edu