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Development of Probes for Monitoring Neurochemistry via Hyperpolarized Xenon MRI
The function of neurochemicals and receptors in the living brain is very difficult to study. We are planning to develop chemical probes that can detect the presence of certain receptors in vitro and in vivo. The probes will be designed to both bind to a specific neuroreceptor and to encapsulate an atom of hyperpolarized xenon. This unique atom is eaily detected using NMR or MRI instruments, and should allow for an accurate measurement of the density of neuroreceptors in the living, whole brain. Students who participate in this project will synthesize and analyze the probe molecules and will be involved in our collaborative efforts to obtain high-resolution images of the rodent brain using the hyperpolarized xenon probes.
 News & Events

RI-INBRE Newsletter Fall 2009

RI-INBRE Newsletter Fall 2009

Grant Workshop PowerPoint Presentations & Handouts

Balancing Teaching and Research at PUIs

Components of a Successful AREA (R15) Grant

NSF-RUI Program: Strategies and Tips for Success

Handouts

Important Dates

RI-INBRE Calendar

12/3//09 - Shahram Khademi, Ph.D, University of Iowa - "The structure and mechanism of ammonia channels"

12/4/09 - 4th Annual BioNES Meeting, Roger Williams University, Bristol, RI

1/29/10 - RI-INBRE Research Fellows Meeting & Faculty Retreat, Providence College, Providence, RI

3/1/10 - Application Deadline for the 2010 Summer Undergraduate Research Fellowships

6/16/10 - 6/18/10 National IDeA Symposium of Biomedical Research Excellence, Bethesda, MD

 Supported by grant #  P20RR016457 from:
Contact Info
Contact RI INBRE:  
University of Rhode Island
Fogarty Hall		 | 41 Lower College Rd | Kingston, RI 02881
Phone: (401) 874-9288 | Fax: (401) 874-2646 | E-mail: riinbre@etal.uri.edu