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A Nuclear Receptor FXR Responsible Element in bile salt export pump promoter
Bile salt export pump (BSEP) is responsible for bile acid removal from the liver and its expression is transcriptionally regulated by nuclear receptor farnesoid-X-receptor (FXR). Impairment of BSEP expression or function is associated with a variety of cholestastic liver injuries. FXR-promoted transactivation of BSEP is mediated through FXR-responsible element (FXRE) in the BSEP promoter. We have identified a potential novel FXRE in the BSEP promoter. The objective of this project is to molecularly and functionally characterize the putative FXRE using regular molecular cloning, cell culture, transfection and promoter reporter assays.
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RI-INBRE Newsletter Fall 2009

RI-INBRE Newsletter Fall 2009

Grant Workshop PowerPoint Presentations & Handouts

Balancing Teaching and Research at PUIs

Components of a Successful AREA (R15) Grant

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Handouts

Important Dates

RI-INBRE Calendar

12/3//09 - Shahram Khademi, Ph.D, University of Iowa - "The structure and mechanism of ammonia channels"

12/4/09 - 4th Annual BioNES Meeting, Roger Williams University, Bristol, RI

1/29/10 - RI-INBRE Research Fellows Meeting & Faculty Retreat, Providence College, Providence, RI

3/1/10 - Application Deadline for the 2010 Summer Undergraduate Research Fellowships

6/16/10 - 6/18/10 National IDeA Symposium of Biomedical Research Excellence, Bethesda, MD

 Supported by grant #  P20RR016457 from:
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University of Rhode Island
Fogarty Hall		 | 41 Lower College Rd | Kingston, RI 02881
Phone: (401) 874-9288 | Fax: (401) 874-2646 | E-mail: riinbre@etal.uri.edu