Regulator of G protein signaling 9-2 (RGS9-2) is a protein that is
highly enriched in the striatum, a brain region that mediates
motivation, movement and reward responses. We have recently
implicated RGS9-2 as a factor in regulating body weight in humans,
rats and mice. For example, we showed that RGS9 gene knockout mice
are heavier than their wild-type littermates, had significantly
higher percentages of abdominal fat and that their constituent
adipocytes had a mean cross-sectional area that was more than double
that of corresponding cells from wild-type mice. Hence, we will
study the cellular functions of RGS9-2 to better understand how the
brain controls body weight and obesity.
*This project involves the use of animals.