Description-AMPs are an exciting new class of
antibiotics rapidly being discovered in diverse species
worldwide-microbes to mammals. My research at URI has focused on using
solid-phase peptide synthesis (SPPS) to prepare diverse combinatorial
libraries of both naturally-occurring and engineered peptides and
developing high-throughput bioassays to characterize their
antimicrobial activity. Our main research foci are in the areas of
Combinatorial Libraries, Antimicrobial Peptide Chemistry, Analytical
Biochemistry, Bioinformatics, and Structural Biology. We investigate
the complex interactions between biopolymers (peptides, proteins, DNA,
RNA, lipids, and carbohydrates) in living systems in order to
understand cellular physiology at the molecular level.
