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Surface Extinction Spectroscopy Based Sandwich Immunoassays with Gold Nanoparticles for Detection of Proteins
There is a great need to develop novel methods to achieve lower limits of detection of biological materials for diagnostics based applications.  One attractive method involves using gold nanoparticles themselves as labels and monitoring the surface plasmon band intensity as a function of the antigen concentration.  We will use this concept to prepare gold nanoparticle bioconjugates as labels for sandwich immunoassays for the detection of proteins.  We will test this concept with biotin-streptavidin bioconjugates and model IgG proteins and then extend it for the detection of clinically relevant proteins and biomarkers.  We will compare the limits of detection achieved with surface extinction spectroscopy compared to other methods.  Students working on this project will gain many valuable skills such as synthesis and characterization of gold nanoparticles, conducting sandwich immunoassays, and surface extinction spectroscopy.
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RI-INBRE Newsletter Fall 2009

RI-INBRE Newsletter Fall 2009

Grant Workshop PowerPoint Presentations & Handouts

Balancing Teaching and Research at PUIs

Components of a Successful AREA (R15) Grant

NSF-RUI Program: Strategies and Tips for Success

Handouts

Important Dates

RI-INBRE Calendar

12/3//09 - Shahram Khademi, Ph.D, University of Iowa - "The structure and mechanism of ammonia channels"

12/4/09 - 4th Annual BioNES Meeting, Roger Williams University, Bristol, RI

1/29/10 - RI-INBRE Research Fellows Meeting & Faculty Retreat, Providence College, Providence, RI

3/1/10 - Application Deadline for the 2010 Summer Undergraduate Research Fellowships

6/16/10 - 6/18/10 National IDeA Symposium of Biomedical Research Excellence, Bethesda, MD

 Supported by grant #  P20RR016457 from:
Contact Info
Contact RI INBRE:  
University of Rhode Island
Fogarty Hall		 | 41 Lower College Rd | Kingston, RI 02881
Phone: (401) 874-9288 | Fax: (401) 874-2646 | E-mail: riinbre@etal.uri.edu