My lab and lab of Prof. Oleg Andreev, at the Division of Biological and
Medical Physics, Physics Department at URI discovered and are developing
novel pHLIPÒ
(pH Low Insertion Peptide) platform technology for cancer imaging and
therapy. pHLIP is a platform technology that allows selective delivery
of diagnostic and/or therapeutic agents to acidic tissues. Acidity is
characteristic of tumors and other pathological states such as ischemia,
stroke, infarction, inflammation, arthritis, and injury, so the pHLIP-delivery
platform may have broad applicability. We have a number of project
student could be assigned from biophysical characterization and chemical
conjugation/purification of pHLIP-imaging and pHLIP-therapeutic agents
to testing of efficacy on cultures cells and in vivo, on mouse models.
All highly motivated students with knowledge and interests in biophysics
or organic chemistry or nanotechnology or cell/cancer biology or animal
studies or optical microscopy and imaging are very welcome to join our
group (http://www.biophys.phys.uri.edu/)
for summer.
