Study of pHLIP-coated
Nanoparticles Interaction with Cancer Cells
We are developing a new pHLIP (pH Low
Insertion Peptide) technology for selective delivery of imaging and
therapeutic agents to acidic diseased tissue such as tumors and ischemic
myocardium. We have published more than 20 papers in PNAS,
Biophysical Journals, Cancer Research and other journals outlying the
design and validation of the family of pHLIP peptides for selective
accumulation in tumors of low extracellular pH. In our recent PNAS
2013 paper w e show targeted delivery of gold nanoparticles to tumors.
Currently, several graduate students are working in our lab to deliver
liposomes, gold and magnetic nanoparticles to tumors. We
investigate interaction of nanoparticles with cells in vitro and in
vivo. The undergraduate student will join a group of graduate students
and will participate in preparation and characterization of
nanoparticles coated with pHLIP and investigate interaction of pHLIP-coated
nanoparticles with cancer cells.
Please note, this project involves the us of vertebrate animals.