Isolation of
bioactive molecules from overlooked bacteria
In the Udwary lab, we have constructed a database of bacterial gene
clusters from the genomes of every sequenced organism available. Any one
of these clusters could produce a novel antibiotic or anticancer agent.
The summer project entails the purchase of one or more of these
promising organisms from a culture collection, growing the culture,
extracting the cells and assaying for bioactivity. As time permits, we
will seek to isolate and identify active compounds. A suitable student
will have some organic chemistry laboratory knowledge, and interest in
natural products, biochemistry, or bioinformatics.