Cytochrome Project
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Faculty:
Professor Roberta King This animation gives the students an 'inside view' of the workings of the enzyme cytochrome P-450 2C9. The protein, represented by the ribbon and yellow spheres, is from an x-ray crystal structure of a drug metabolizing enzyme called cytochrome P-450 2C9. The larger of the two ligands (clusters of spheres) is the heme which acts as cofactor to assist in the catalytic reaction. The smaller of the two ligands is the drug warfarin (an anticoagulant) which is the substrate for the catalytic reaction. |
Quicktime player is needed to view the above animation. Visit the Pharmacy page for more pharmaceutical animations.
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| First both ligands are bound. Then the warfarin molecule moves from solution (outside the protein) and finds a channel by which to access its specific binding site. The warfarin molecule finds its way through the channel to find its preferred binding position near the active site. | |
For more information on any of the above projects, please contact Roy Bergstrom.
