Lenore M. Martin, Ph.D.

Martin, Lenore M. "Synthesis of Small Molecules to Probe Deoxyribonucleic Acid Binding". Ph.D. Thesis, March 1989
under Professor Orville L. Chapman, Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA).

Contact Information:        (401) 874-5049                       martin@uri.edu

Department Secretary: (401) 874-2201    FAX (401)874-2202

Mailing Address:

Department of Cell and Molecular Biology (CMB)
Morrill Hall Room 117
45 Lower College Road
Kingston, RI 02881 USA

Courses Taught:

Research Interests:

Modeling protein structural motifs via solid-phase synthesis (SPS) of small proteins, peptides and peptidomimetics. Design and synthesis of novel therapeutic agents using natural scaffolds such as peptides and DNA. Development of combinatorial libraries for the generation and screening of novel antibiotics and anti-tumor agents. Investigation of topoisomerase inhibition mechanisms and mechanisms of action of peptide antibiotics.  Analysis of the biophysical properties of peptides and proteins by capillary electrophoresis (CE).

Publications:

  1. "Synthetic Studies on the Antimicrobial Activity of Pleurocidin" by Lenore M. Martin, Khaled A. Elsaid, Tarquin Dorrington, and Marta Gómez-Chiarri in Peptides: The Wave of the Future, Richard A. Houghten and Michal Lebl eds.  Kluwer Academic Publishers, Dordrecht, The Netherlands (2001) 475-476.
  2. "Thiazole and Oxazole Building Blocks for Combinatorial Synthesis" by Lenore M. Martin and Bi-Huang Hu.  Tetrahedron Letters 40 (1999) 7951-53.
  3.     "Design, Synthesis, and Antibacterial Activity of a Peptidomimetic Library" by Bi-Huang Hu and Lenore M. Martin.  In Peptides for the New Millenium; Fields, Gregg B. Tam, James P., and Barany, George eds., Kluwer Academic Publishers, Dordrecht, The Netherlands, 2000, pp. 746-47.
  4.      "Synthetic Peptide Analogs Compared with Phage Display" by Lenore M. Martin, Bradley Messmer, and David Thaler. In Peptides for the New Millenium; Fields, Gregg B. Tam, James P., and Barany, George eds., Kluwer Academic Publishers, Dordrecht, The Netherlands, 2000, pp.172-173.
  5.   "A Robust Method for Determining DNA Binding Constants Using Capillary Zone Electrophoresis" by  Chunze Li and Lenore M. Martin Analytical Biochemistry. 263 (1998) pp. 72-78.
  6.   "Enantiomeric Structural Libraries of Unnatural Peptides Which Bind DNA and Alter Enzymatic Activity" by Lenore M. Martin, Chunze Li and Bi-Huang Hu.  In Peptides: Frontiers of Peptide Science;  Tam, J.P. and Kaumaya, P. eds., Kluwer Academic Publishing, Dordrecht, The Netherlands, 1999, pp.122-123.
  7.     "Capillary Electrophoresis of Peptides and Proteins" by Bi-Huang Hu and Lenore M. Martin.  In  High-Resolution Chromatography: A Practical Approach,  Millner, P.A. Ed. IRL/Oxford University Press: Oxford, 1999, pp. 77-117.
  8.     "Antibody Fragment Separations by Capillary Zone Electrophoresis" by Lenore M. Martin    Journal of Chromatography  B: Biomedical Applications. 675 (1996) pp. 17-25.
  9.   "Facile Reduction in the Synthesis of Phosphorylcholine Affinity Columns"  by Lenore M. Martin    Tetrahedron Letters, 37(44) (1996); pp. 7921-24.
  10.     "The Use of Ion-Pairing Reagents Improves the Separation of Hydrophobic Peptides by Capillary Electrophoresis" by Lenore M. Martin in Peptides: Chemistry and Biology; Kaumaya, P.T.P. and Hodges, R. Eds. Mayflower Press, 1996, pp. 144-145.
  11.     "McPC603 VH(1-115): Synthesis and Folding of Immunoglobulin Variable Regions" by Lenore M. Martin, Kenneth S. Rotondi and R.B. Merrifield in Peptides: Chemistry and Biology, Hodges, R. Smith, John A. Eds. ESCOM: Leiden, 1994,  pp. 249-51.
  12.     "Synthesis and Characterization of Immunoglobulin Variable Region Heavy and Light Chain  Fragments"  by Lenore M. Martin and R.B. Merrifield.  In  Peptides: Chemistry and Biology; Smith, John A.; Rivier, Jean E. Eds.; ESCOM: Leiden, 1992, pp 849-50.
My Research Students
 

Mr. Khaled Elsaid - M.S. 2002 


Dr. Bi-Huang Hu
Ph.D. 1999
Now at  NU Medical School 
 

Ms. Chunze Li - Masters  1997- Now at UCSF
Mr. Devin Pray - Undergraduate Research, 1998-99 - Now at UCONN (in Collaboration with Prof. Linda Hufnagel)

Phage Library Collaborators Meeting at The Rockefeller University

Dr. Brad Messmer, Dr. David Thaler, and Dr. Lenore Martin


Chatting with a colleague at the Speakers Dinner during the 16th American Peptide Symposium in Minneapolis, MN June 1999
 
 


Displaying result of latest total synthesis of a natural product - Leah Elizabeth Ribner-Martin - Born February 20, 2001-
at the 17th American / 2nd International peptide Symposium in San Diego, CA June 2001.

    Professional Society Memberships / Activities

    Sigma Xi: URI Chapter President 1999-2000, URI Chapter Secretary 1996-1998. Chaired session on Peptide Immunology at the 16th American Peptide Symposium in Minneapolis MN, June 1999.  Attended the Gordon Conference on Peptides, Chemistry and Biology, 1996 and 1998. Chaired session on Regulatory Affairs at HPLC ’98 in St. Louis MO.  Co-Chair of North East Regional Medicinal Chemistry and Pharmacognosy meeting (NERMCAP), RI, 1995 and 1999. Founding member, American Peptide Society.  Founding member, ROCKMUG.  Organized symposium "Frontiers in Chemistry," sponsored by the ACS younger chemists committee 1987. UCLA Chemistry Department Safety Committee, 4 years. Member American Chemical Society, American Peptide Society, American Association of Colleges of Pharmacy, American Women in Science and American Association for the Advancement of Science. Honor Societies: Rho Chi, 1994. Sigma Xi, 1989, Graduate Women in Science, 1987. Phi Lambda Upsilon - Chemistry Honor Society, 1982.

    Links to other related sites:

    American Peptide Society
    Association of Biomolecular Resource Facilities
    Combinatorial Chemistry Site
    Connecticut Separation Science Council
    Journal of Peptide Research
    Journal of Peptide Science
    Molecular Diversity
    Organic database
    Protein Data Base (RCSB)
    Sigma Xi Site