Department Chair
Clinton O. Chichester, Ph.D.
Professor of Pharmacology and Toxicology
chichester@uri.edu
Dr. Chichester's teaching and research
interests are in pharmacology and in connective tissue metabolism. In
addition Dr. Chichester is also Director of the Learning Resource Center
in that capacity oversees computer technology in the College.
Ph.D. in Pharmaceutical Sciences,
University of Rhode Island, 1980
M.S. in Pharmacology and Toxicology,
University of Rhode Island, 1977
B.S. in Biochemistry, University of
California, 1973
Research Interests:
Connective tissue pharmacology
Collagen degradation in osteoarthritis
Alterations in drug metabolism in septic
shock
Selected Publications:
Mackay, A.M., Beck, S.C., Murphy, J.M.,
Barray, F.P., Chichester, C.O. and Pittenger, M.R. Chondrogenic
Differentiation of Cultured Human Mesenchmal Stem Cell from Marrow.
Tissue Engineering 4: 415-428, 1998
Felice, B.R., Chichester, C.O. and
Barrach, H.-J. Type II Collagen Peptide Release from Rabbit Articular
Cartilage. Ann. N.Y. Acad. Sci.
878: 590-593, 1999
McKindley, D.S., Chichester, C.O.,
Raymond, R. Effect of Endotoxin Shock on the Clearance of Lidocaine and
Indocyanine Green in the Perfused Rat Liver.
Shock. 12:468-472, 1999
Rogart, J.N., Barrach, H.-J., and
Chichester, C.O. Articular Cartilage Degradation in the Hulty-Telhag
Model of Osteoarthristis. Osteoarthritis and Cartilage.
7:539-547, 1999
McKindley, D.S., Boulet, J., Sachdeva,
K., Wang, P., Chichester, C.O. Endotoxic shock alters the
pharmacokinetics of lidocaine and monethylglycinexylidide. Shock.
17:199-204, 2002.
Jay GD, Elsaid KA, Zack J, Robinson K,
Trespalacois F, Cha CJ, Chichester CO. Lack of chondroprotection occurs
among emergency department patients with knee joint synovitis.
J Rheum
31:557-564, 2004.
Chichester C. O, Felice B. R.
Simulations in Pharmacology, in Practical Health Care Simulations,
p. 143-158, Loyd G. E., Lake C. L., Greenberg R. B. eds. Elsevier
Mosby 2004.
Ma Y,Sachdeva K,
Liu J,Ford M, Yang D, Khan IA, Chichester CO, and Yan B.
Desmethoxyyangonin and dihydromethysticin are two major pharmacological
kavalactones with potent activity on the induction of cytochrome
P4503A23. Drug Metabolism and Disposition
32:1317-1324,2004.
Mills, L. J and Chichester C. Review of
the evidence: Are endocrine-disrupting chemicals in the aquatic
environment impacting fish populations? Sci Total Enviorn
343:1-34, 2005.
Ma Y, Sachdeva K, Liu, J, Song X, Li X,
Dongfang Y., Deng R , Chichester CO, Yan B, Clofibrate and
perfluorodecanoate both up regulate the expression of the pregnane X
receptor but oppositely affect its ligand-dependent induction on
cytochrome P450 3A23. Bioch Pharm
69:1363-1371, 2005.
Elsaid KA, Jay GD, Warman ML, Rhee
DK, Chichester CO, Association of articular cartilage degradation and
loss of boundary-lubricating ability of synovial fluid following injury
and inflammatory arthritis. Arthritis and Rheum
52:1746-55,2005.
For more
information, contact:
College of Pharmacy
Fogarty Hall, 41 Lower College Road, Kingston, RI 02881
Phone: 401-874-5842, Fax: 401-874-2181
E-mail:
pharmcol@etal.uri.edu.
The
University is an affirmative action/equal opportunity employer.
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