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Bongsup
P. Cho, Ph.D.
Professor of Medicinal Chemistry
bcho@uri.edu
Click here for information
about Dr. Cho's lab
Education
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Ph.D., University of Illinois, 1985
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M.S., Yonsei University, Seoul, Korea, 1979
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B.S., Yonsei University, Seoul, Korea, 1977
Research Interests:
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Chemical carcinogenesis of polyarenes and their amino and nitro derivatives with
major emphasis on the molecular consequence of adduct formation in DNA
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Structural biology of carcinogen (drug)-macromolecular interactions, mechanisms of
mutation, DNA adduct chemistry.
Publications:
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Product Ion Studies of
Diastereomeric Benzo[ghi]fluoranthene Adducts of Deoxyadenosine by
Electrospray Ionization and Quadrupole Ion Trap Mass Spectrometry,
Acta Chemica Acta, 557, 191-197 (2006).
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T. Yang, Y. Huang, and B. P. Cho.
Synthesis and Characterization of Enantiomeric
anti-2-Fluorobenzo[a]pyrene- 7,8-dihydrodiol-9,10-epoxides and their
2’-Deoxyguanosine and Oligodeoxynucleotide Adducts. Chem. Res.
Toxicol., 19, 242-254 (2006).
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S. R. Meneni, R. D’Mello, G.
Norigian, G. Baker, L. Gao, M. P. Chiarelli, and B. P. Cho. Sequence
effects of aminofluorene- modified DNA duplexes: UV thermodynamic and
circular dichroism properties. Nucleic Acids Res., 34, 755-763
(2006).
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F. Liang, S. Meneni and B. P. Cho.
Induced Circular Dichroism Characteristics as Conformational Probes for
Carcinogenic Aminofluorene-DNA Adducts, Chem. Res. Toxicol., 19,
1040-1043 (2006).
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S. Meneni, S. M. Shell, Y. Zou, and
B. P Cho. Conformation-specific Recognition of Carcinogen-DNA Adduct in
E. coli. Nucleotide Excision Repair. Chem.. Res. Toxicol., 20,
6-10 (2007).
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S. Meneni, F. Liang and B. P. Cho.
Examination of the long-range effects of aminofluorene-induced
conformational heterogeneity and its relevance to the mechanisms of
translesion DNA synthesis. J. Mol. Biol., 366, 1387-1400
(2007).
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S. Meneni, S. M. Shell, L. Gao, P.
Jurecka, W. Lee, J. Sponer, Y. Zou, M. P. Chiarelli, and B. P. Cho.
Spectroscopic and Theoretical Insights into Sequence Effects of
Aminofluorene-induced Conformational Heterogeneity and Nucleotide
Excision Repair. Biochemistry, 40, 11263-11278 (2007).
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F. Liang and B. P. Cho. Probing the
Thermodynamics of Aminofluorene-Induced Translesion DNA Synthesis by
Differential Scanning Calorimetry. J. Am. Chem. Soc. (Communication),
129, 12108-12109 (2007).
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Nidhi Jain, Yuyuan Li, Li Zhang,
Srinivasa Meneni, and Bongsup Cho, Probing the Sequence Effects on NarI-Induced
-2 Frameshift Mutagenesis by Dynamic 19F NMR, UV, and CD
Spectroscopy, Biochemistry, 46, 13310-13321 (2007).
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N. Jain, Y. K. Reshetnyak, L. Gao,
M. P. Chiarelli, and B. P. Cho. Fluorescence probing of aminofluorene-induced
conformational heterogeneity in DNA duplexes, Chem. Res. Toxicol.
21, :445-452
(2008).
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