Ruitang Deng, Ph.D.
Assistant Professor
dengr@mail.uri.edu

Education:
 

• Postdoctoral, University of Massachusetts Medical School, 1996
• Ph.D., Ohio State University, 1992
• M.S., Nanjing Agricultural University, 1986
• B.S., Zhejiang (Agricultural) University, 1983

Research Interests:
 

• Bile acids and cholesterol homeostasis, regulation and related diseases
• Drug transporters and toxicology
• Biological and pharmaceutical therapy development

Publications:
 

• Song X, Kaimal R, Yan B and Deng R (2008) Orphan nuclear receptor liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression. J Lipid Res. 49:973-984
   

• Liu FJ, Song X, Yang D, Deng R, Yan B (2008) The far and distal enhancers in the CYP3A4 gene coordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Biochem J. 409:243-250.
   

• Deng R (2007) Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovascular Drug Reviews. 25:375-390
   

• Deng R, Radke A, Yang J and Yan B (2007) Hypolipidemic Agent Guggulsterone Regulates the Expression of Human Bile Salt Export Pump: Dominance of Transactivation over FXR-Mediated antagonism. J Pharmacol Exp Ther. 320:1153-1162.
   

• Deng R, Yang D, Yang J, Yan B (2006) Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor FXR but not LXR. J. Pharmacol. Exp. Ther. 317: 317-325.
   

• Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006) The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogen. 25: 3296-3306.
   

• Ma Y, Song X, Sachdeva K, Liu J, Li Y, Yang D, Deng R, Chichester CO, Yan B (2005) Clofibrate and perfluorodecanoate both up-regulate the expression of the pregnane X receptor but only clofibrate enhances its ligand-dependent induction of cytochrome P4503A23. Biochem.  Pharmacol. 69, 1363-1371.
   

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