Bingfang Yan, Ph.D.
Professor of Pharmacology and Toxicology
byan@uri.edu

Click here for information about Dr. Yan's lab

Education

• Ph.D., University of Kansas, 1994

• M.S., Nanjing Agricultural University, 1985

• D.V.M., Huazhong Agricultural School of Veterinary Medicine, 1982

Research Interests:

• Genetic-based alteration on drug response

• Drugs, herbs, hormones, and their interaction

• Cancer: initiation, progression and chemoresistance

• Transcription regulation

Publications (last three years):

1. Xie M, Yang D, Wu M, Xue B, Yan B (2003) Mouse carboxylesterase M-LK rapidly hydrolyzes antitumor prodrug CPT-11 and the N-terminal three quarter sequence determines substrate selectivity. Drug Metab Dispos.  31: 21-27.

2. Sachdeva K, Yan B, Chichester CO (2003) Lipopolysaccharide and cecal ligation/puncture differen­ti­ally affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target gene CYP3A. Shock. 19: 470-475.

3. Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 278: 16899-16907.

4. Wyde ME, Bartolucci E, Ueda A, Zhang H, Yan B, Negishi M, You L (2003) The environmental pollutant DDE induces hepatic cytochrome P450 2B and 3A expression through activating the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Mol Pharmacol. 64: 474-481.

5. Xie M, Yang D, Matoney L, Yan B (2003) Rat NTE-related esterase is a membrane-associated protein, hydrolyzes lipophilic esters and interacts with diisopropyl­fluoro­phosphate through serine catalytic machinery. Arch Biochem Biophys. 416: 137-146.

6. Nam NH, Pitts R, Sun G, Sardari S, Tiemo A, Xie M, Yan B, Parang K (2004) Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. Bioorgan & Med Chem. 12: 779-787.

7. Song X., Xie M, Zhang H, Li Y, Sachdeva K, Yan B (2004) The pregnane X receptor binds to response elements in a genomic context-dependent manner and its activator rifampicin selectively alters the bindings among target genes. Drug Metab Dispos. 32: 35-42.

8.  Song X, Gragen S, Li Y, Ma Y, Liu J, Yang D, Matoney L, Yan B (2004) Intramolecular disulfide bridges are required for folding hydrolase B into a catalytically active conformation but not for maintaining it during catalysis. Biochem Biophys Res Commun. 319: 1072-1080.

9. Li Y, Song X, Ma Y, Liu J, Yang D, Yan B (2004) DNA binding, but not interaction with BmalI, is responsible for DEC1-mediated transcription regulation of the circadian gene Per1. Biochem J. 382: 895-904.

10. Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL (2004) Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 32: 348-58.

11. Ma Y, Sachdeva K, Liu J, Ford M, Yang D, Khan IA, Chichester CO, Yan B (2004) Desmethoxy­yangonin and dihydro­methysticin are two major pharmacological kavalactones with potent activity on the induction of cytochrome P4503A23. Drug Metab Dispos. 32: 1317-1324.

12. Song X, Li Y, Liu J, Mukundan M, Yan B (2005) Simultaneous substitution of phenylalaine-305 and aspartate-318 of rat PXR by the corresponding human residues abolishes the ability to transactivate the cytochrome P4503A23 promoter. J Pher Exp Ther. 312: 571-582.

13. Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan YS (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med. 15: 633-640.

14. Hokeness K, Qiu LH, Vezeridis M, Yan B, Mehta S, Wan YS (2005) Paclitaxel-induced apoptosis in cultured human keratinocytes is enhanced by IFN-g and is modulated by activation of caspase 8 and 3 with a concomitant down regulation of the AKT survival pathway. Oncology Report. 13: 965-969.

15. Pope CN, Karanth S, Liu J, Yan B (2005) Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul Toxicol. Pharm. 42: 62-69.

16. Ma Y, Song X, Sachdeva K, Liu J, Li Y, Yang D, Deng R, Chichester CO, Yan B (2005) Clofibrate and perfluorodecanoate both up-regulate the expression of the pregnane X receptor but only clofibrate enhances its ligand-dependent induction of cytochrome P4503A23. Biochem Pharmacol. 69: 1363-1371.

17. Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, Bartolucci-Page E, Gaido KW, Yan B, You L (2005) Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses. Toxicol Sci. 86: 281-290.

18. Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan Y (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med. 15: 633-640.

19. Qiu L, Wang Q, Di W, Jiang Q, Schefeller E, Derby S, Wanebo H, Yan B, Wan Y (2005) Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. Int J Oncol. 27: 823-30.

20. Qiu L, Di W, Jiang Q, Scheffler E, Derby S, Yang J, Kouttab N, Wanebo H, Yan B, Wan Y (2005) Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. Int J Oncol. 27: 1441-8.

21. Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2005) The expression of antiapoptotic protein survivin is trans­criptionally upregulated by DEC1 primarily through multiple Sp1 binding sites in the proximal promoter.  Oncogene. In press.     

22. Deng R, Yang D, Yang J, Yan B (2005) Cholesterol oxylsterol transcriptionally induces the expression of the bile salt efflux pump through the farnesoid X receptor but not the liver X receptor. J Pher Exp Ther. Accepted.

23. Gong X, Tsai SW, Yan B, Rubin LP (2006) PPARg is essential but not sufficient to activate human intestinal b,b,-carotene 15,15’-oxygenase gene expression: role of MEF2C. J Biol Chem. Submitted.

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