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Faculty and Staff
Chichester  

Clinton O. Chichester, Ph.D.

Department Chair
Professor of Pharmacology and Toxicology
Department of Biomedical and Pharmaceutical Sciences
chichester@uri.edu
     

Research Interests

  

Dr. Chichester's teaching and research interests are in pharmacology and in connective tissue metabolism. In addition Dr. Chichester is also Director of the Learning Resource Center in that capacity oversees computer technology in the College.

  • Connective tissue pharmacology
  • Collagen degradation in osteoarthritis
  • Alterations in drug metabolism in septic shock
     

Education

  

Ph.D. in Pharmaceutical Sciences, University of Rhode Island, 1980

M.S. in Pharmacology and Toxicology, University of Rhode Island, 1977

B.S. in Biochemistry, University of California, 1973
     

 

  

     

Residency/Fellowship

  

Clinical Pharmacy Residency, University of Illinois at Chicago, 1982-198

American Heart Association Fellow in Cardiovascular Disease Prevention and Epidemiology,1997
     
Selected Publications  

Mackay, A.M., Beck, S.C., Murphy, J.M., Barray, F.P., Chichester, C.O. and Pittenger, M.R. Chondrogenic Differentiation of Cultured Human Mesenchmal Stem Cell from Marrow. Tissue Engineering 4: 415-428, 1998

Felice, B.R., Chichester, C.O. and Barrach, H.-J. Type II Collagen Peptide Release from Rabbit Articular Cartilage. Ann. N.Y. Acad. Sci. 878: 590-593, 1999

McKindley, D.S., Chichester, C.O., Raymond, R. Effect of Endotoxin Shock on the Clearance of Lidocaine and Indocyanine Green in the Perfused Rat Liver. Shock. 12:468-472, 1999

Rogart, J.N., Barrach, H.-J., and Chichester, C.O. Articular Cartilage Degradation in the Hulty-Telhag Model of Osteoarthristis. Osteoarthritis and Cartilage. 7:539-547, 1999

McKindley, D.S., Boulet, J., Sachdeva, K.,  Wang, P., Chichester, C.O. Endotoxic shock alters the pharmacokinetics of lidocaine and monethylglycinexylidide. Shock. 17:199-204, 2002.

Jay GD, Elsaid KA, Zack J, Robinson K, Trespalacois F, Cha CJ, Chichester CO. Lack of chondroprotection occurs among emergency department patients with knee joint synovitis. J Rheum 31:557-564, 2004.

Chichester C. O, Felice B. R. Simulations in Pharmacology,  in Practical Health Care Simulations, p. 143-   158, Loyd G. E., Lake C. L., Greenberg R. B. eds. Elsevier Mosby 2004.

Ma Y, Sachdeva K, Liu J, Ford M, Yang D, Khan IA, Chichester CO, and Yan B.  Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with potent activity on the induction of cytochrome P4503A23. Drug Metabolism and Disposition 32:1317-1324,2004.

Mills, L. J and Chichester C. Review of the evidence: Are endocrine-disrupting chemicals in the aquatic environment impacting fish populations? Sci  Total  Enviorn 343:1-34, 2005.

Ma Y, Sachdeva K, Liu, J, Song X, Li X, Dongfang Y., Deng R , Chichester CO, Yan B, Clofibrate and perfluorodecanoate both up regulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. Bioch Pharm 69:1363-1371, 2005.

Elsaid KA, Jay GD, Warman ML, Rhee DK, Chichester CO, Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis and Rheum 52:1746-55,2005.