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Faculty and Staff
Cho  

Bongsup P. Cho, Ph.D.

Professor of Medicinal Chemistry
Department of Biomedical and Pharmaceutical Sciences
bcho@uri.edu

Click here for information about Dr. Cho's lab
     

Research Interests

  
  • Chemical carcinogenesis of polyarenes and their amino and nitro derivatives with   major emphasis on the molecular consequence of adduct formation in DNA
  • Structural  biology of carcinogen (drug)-macromolecular interactions, mechanisms of mutation,  DNA adduct chemistry.
     

Education

  

Ph.D., University of Illinois, 1985

M.S., Yonsei University, Seoul, Korea, 1979

B.S., Yonsei University, Seoul, Korea, 1977

     
Selected Publications  

S. Meneni, S. M. Shell, Y. Zou, and B. P Cho. Conformation-specific Recognition of Carcinogen-DNA Adduct in E. coli. Nucleotide Excision Repair. Chem.. Res. Toxicol. 20, 6-10 (2007).

S. Meneni, F. Liang and B. P. Cho. Examination of the long-range effects of aminofluorene-induced conformational heterogeneity and its relevance to the mechanisms of translesion DNA synthesis. J. Mol. Biol.., 366, 1387-1400 (2007).

S. Meneni, S. M. Shell, L. Gao, P. Jurecka, W. Lee, J. Sponer, Y. Zou, M. P. Chiarelli, and B. P. Cho. Spectroscopic and Theoretical Insights into Sequence Effects of Aminofluorene-induced Conformational Heterogeneity and Nucleotide Excision Repair. Biochemistry, 40, 11263-11278 (2007).

F. Liang and B. P. Cho. Probing the Thermodynamics of Aminofluorene-Induced Translesion DNA Synthesis by Differential Scanning Calorimetry. J. Am. Chem. Soc. (Communication), 129, 12108-12109 (2007).

Nidhi Jain, Yuyuan Li, Li Zhang, Srinivasa Meneni, and Bongsup Cho, Probing the Sequence Effects on NarI-Induced -2 Frameshift Mutagenesis by Dynamic 19F NMR, UV, and CD Spectroscopy, Biochemistry, 46, 13310-13321 (2007).

N. Jain, Y. K. Reshetnyak, L. Gao, M. P. Chiarelli, and B. P. Cho. Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes, Chem. Res. Toxicol. 21, 445-452 (2008).

L. Gao, L. Zhang, B. P. Cho, and M. P. Chiarelli. Sequence Verification of Oligonucleotides Containing Multiple Arylamine Modifications by Enzymatic Digestion and Liquid Chromatography Mass Spectrometry (LC/MS). J. Am. Mass. Spectrom., 19, 1147-1155 (2008).

F. Liang, N. Jain, T. Hutchens, D. D. Shock, W. A. Beard, S. H. Wilson, M. P. Chiarelli, and B. P. Cho &alhpa;,ß-Methylene-2’-deoxynucleoside 5’-triphosphates as non-cleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2’-deoxycyclonucleosides, 3,5’-anhydro-dG and 2,5’-anhydro-dT. J. Med. Chem., 51, 6460 (2008).

N. Jain, S. Meneni, and B. P. Cho. Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes. Nucleic Acids Res. 2009 Jan 16. [Epub ahead of print]