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Faculty and Staff
Deng  

Ruitang Deng, Ph.D.

Associate Professor
Department of Biomedical and Pharmaceutical Sciences
dengr@mail.uri.edu
     

Research Interests

  
  • Bile acids and cholesterol homeostasis, regulation and related diseases
  • Drug transporters and toxicology
  • Biological and pharmaceutical therapy development
     

Education

  

Postdoctoral, University of Massachusetts Medical School, 1996

Ph.D., Ohio State University, 1992

M.S., Nanjing Agricultural University, 1986

B.S., Zhejiang (Agricultural) University, 1983
     
Selected Publications  

Song X, Kaimal R, Yan B and Deng R (2008) Orphan nuclear receptor liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression. J Lipid Res. 49:973-984

Liu FJ, Song X, Yang D, Deng R, Yan B (2008) The far and distal enhancers in the CYP3A4 gene coordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Biochem J. 409:243-250.

Deng R (2007) Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovascular Drug Reviews. 25:375-390

Deng R, Radke A, Yang J and Yan B (2007) Hypolipidemic Agent Guggulsterone Regulates the Expression of Human Bile Salt Export Pump: Dominance of Transactivation over FXR-Mediated antagonism. J Pharmacol Exp Ther. 320:1153-1162.

Deng R, Yang D, Yang J, Yan B (2006) Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor FXR but not LXR. J. Pharmacol. Exp. Ther. 317: 317-325.

Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006) The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogen. 25: 3296-3306.

Ma Y, Song X, Sachdeva K, Liu J, Li Y, Yang D, Deng R, Chichester CO, Yan B (2005) Clofibrate and perfluorodecanoate both up-regulate the expression of the pregnane X receptor but only clofibrate enhances its ligand-dependent induction of cytochrome P4503A23. Biochem.  Pharmacol. 69, 1363-1371.