Ph.D., University of Iowa, 1995,
Medicinal and Natural Products Chemistry
B.S., University of Kansas, 1989,
Chemistry
Research Interests:
Biotransformation and Chemical Toxicology
Sulfotransferase
biochemistry and physiological effects of inhibition.
Mechanisms causing
inter-individual variation in metabolism.
Biotransformation of
heterocyclic amine carcinogens in animal models and human tissues.
Publications:
King RS, Teitel CH, Shaddock JG,
Casciano DA and Kadlubar FF (1999) Detoxification of carcinogenic
aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy
derivative. Cancer Letters, 143:167-171.
King RS, Kadlubar FF and Turesky RJ
(2000) In vivo
metabolism of heterocyclic amines, in Food Borne Carcinogens:
Heterocyclic Amines (Sugimura T and Nagao M eds) pp. 90-111, John
Wiley and Sons Ltd, London.
King RS, Teitel CH, Kadlubar FF
(2000) In vitro bioactivation of N-hydroxy-2-amino-a-carboline.
Carcinogenesis, 21:1347-1354.
King RS, Sharma V, Pedersen LC,
Kakuta Y, Negishi M and Duffell MW (2000) Structure-Function Modeling of
the Interactions of N-Alkyl-N-Hydroxyanilines with Rat
Hepatic Aryl Sulfotransferase IV. Chemical Research in Toxicology,
13:1251-1258.
For more
information, contact:
College of Pharmacy
Fogarty Hall, 41 Lower College Road, Kingston, RI 02881
Phone: 401-874-5842, Fax: 401-874-2181
E-mail:
pharmcol@etal.uri.edu.
The
University is an affirmative action/equal opportunity employer.
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