|
 |
|
Abraham Kovoor, Ph.D.
Assistant Professor
abekovoor@uri.edu
Education:
-
Postdoctoral, University of California, San Francisco, 2006
-
Postdoctoral, Stanford University, Stanford, California, 2003
-
Postdoctoral, California Institute of Technology, Pasadena, 2002
-
Ph.D. Molecular Pharmacology, Dept. of Pharmacology, University of
Washington, Seattle, 1998
-
B. Pharmacy, Birla Institute of Technology and Science, Pilani, India,
1991
Research Interests:
- Molecular mechanisms underlying the
pharmacotherapy of schizophrenia and Parkinson’s disease.
- Signaling mechanisms and regulation of
seven pass transmembrane G protein coupled receptors.
Publications:
1. Kovoor A,
Seyffarth P, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BNR,
Simon MI, Lester HA, Schwarz J. D2 dopamine receptors colocalize RGS9 2
via the RGS9 DEP domain and RGS9 knockout mice develop dyskinesias
associated with dopamine pathways. Journal of Neuroscience, 2005 Feb
23, 25(8):2157-65.
2. Kovoor A and
Lester HA. RGS proteins accelerate the deactivation kinetics of GIRK
channels but steady-state amplitudes and the forward rate of activation
are unchanged. (in preparation).
3. Rahman Z,
Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Neve RL,
Lester HA, Simon MI and Nestler EJ. RGS9 Modulates Dopamine Signaling
in the Basal Ganglia. Neuron, 2003 Jun 19;38(6):941-52.
4. Kovoor A, Lester
HA. Gi Irks GIRKs. Neuron, 2002 Jan 3;33(1):6-8.
5. Celver JP, Lowe
J, Kovoor A. Gurevich VV, Chavkin C. Threonine 180 is required for GRK3
and arr3 mediated desensitization of the Mu opioid receptor in Xenopus
oocytes. Journal of Biological Chemistry, 2001 Feb 16;276(7):4894-900.
6. Kovoor A, Chen
CK, He W, Wensel TG, Simon MI, Lester HA. Co-expression of Gbeta5
enhances the function of two G gamma subunit-like domain-containing
regulators of G protein signaling proteins. Journal of Biological
Chemistry,. 2000 Feb 4; 275(5):3397-402.
7. Appleyard SM,
Celver J, Pineda V, Kovoor A, Wayman GA, Chavkin C. Agonist-dependent
desensitization of the kappa opioid receptor by G protein receptor
kinase and beta-arrestin. Journal of Biological Chemistry, 1999 Aug 20,
274(34):23802-7.
8. Jin W, Brown S,
Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K. Distinct
domains of the CB1 cannabinoid receptor mediate desensitization and
internalization. Journal of Neuroscience, 1999 May 15, 19(10):3773-80.
9. Kovoor A, Celver
J, Abdryashitov RI, Chavkin C, Gurevich VV. Targeted construction of
phosphorylation-independent beta-arrestin mutants with constitutive
activity in cells. Journal of Biological Chemistry, 1999 Mar 12,
274(11):6831-4.
10. Kovoor A, Celver
JP, Wu A, Chavkin C. Agonist induced homologous desensitization of mu-opioid
receptors mediated by G protein-coupled receptor kinases is dependent on
agonist efficacy. Molecular Pharmacology, 1998 Oct, 54(4):704-11.
11. Kovoor A, Nappey
V, Kieffer BL, Chavkin C. Mu and delta opioid receptors are
differentially desensitized by the coexpression of beta-adrenergic
receptor kinase 2 and beta-arrestin 2 in Xenopus oocytes. Journal of
Biological Chemistry, 1997 Oct 31, 272(44):27605-11.
12. Kovoor A, Henry
DJ, Chavkin C. Agonist-induced desensitization of the mu opioid
receptor-coupled potassium channel (GIRK1). Journal of Biological
Chemistry, 1995 Jan 13, 270(2):589-95.
|
