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Faculty and Staff
Parang  

Keykavous Parang, Pharm. D., Ph.D.

Professor of Medicinal Chemistry
Department of Biomedical and Pharmaceutical Sciences
kparang@uri.edu

Click here for information about Dr. Parang's lab
     

Research Interests

  

Our research is appropriately described as "the application of synthetic organic chemistry to problems in biology". Specific areas currently under investigation include:

  • Designing Protein Kinase Inhibitors Through Target-Based Strategies Using Synthetic, Molecular Modeling, and Biochemical Tools.
  • Novel Strategies in the Solid-Phase Synthesis.
  • Novel Approaches in Designing Multifunctional Anti-Cancer and Anti-HIV Agents.
  • Designing Peptide Nanostructures.
  • Peptide- and Polymer-Based Drug Delivery.
     

Education

  

Postdoctoral Fellow, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 2000
Postdoctoral Fellow, Department of Bioorganic Chemistry, Rockefeller University, 1999
Postdoctoral Fellow, Department of Chemistry, University of Alberta, 1998
Ph.D., University of Alberta, 1997
Pharm.D., Faculty of Pharmacy, University of Tehran, 1989
     
   
     
Selected Publications  

Out of 95 Publications (May 2011)  Click here for complete list.

1. Kumar, A., Ahmad, I, Chhikara, B. S., Tiwari, R., Mandal, D., Parang, K. Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities. Bioorg. Med. Chem. (2011) 21, 1342-1346.

2. Agarwal, H. K., Loethan, K., Mandal, D., Doncel, G. F. Parang, K. Synthesis and anti-HIV activities of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine. Bioorg. Med. Chem. (2011) 21, 1917-1921.

3. Chhikara, B. S., St. Jean, N., Mandal, D., Kumar, A., Parang, K. Fatty-acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities. Eur. J. Med. Chem. (2011) 46, 2037-2042.

4. Agarwal, H. K., Kumar, A., Doncel, G. F., Parang K. Synthesis, antiviral and contraceptive activities of nucleoside-sodium cellulose sulfate acetate and succinate conjugates. Bioorg. Med. Chem. Lett. (2010) 20, 6993-6997.

5. Chhikara, B. S., Mandal, D., Parang, K. Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents. Eur. J. Med. Chem. (2010) 45, 4601-4608.

6. Ahamadibeni, Y., Tiwari, R., Sun, G., Parang, K. Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cycloSaligenyl phosphitylating reagents. Org. Lett. (2009) 11, 2157-2160.

7. Penugonda,S., Kumar, A., Agarwal, H. K., Parang, K., Mehvar, R. Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: Effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates. J. Pharm. Sci. (2008) 97, 2649-2664.

8. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of symmetrical 5’,5’-dinucleoside mono-, di-, tri-, and tetraphosphodiesters. Org. Lett. (2007) 9, 4483-4486.

9. Bhandari, R., Saiardi, A., Ahmadibeni, Y., Snowman, A. M., Resnick, A. C., Kristiansen, T. Z., Molina, H., Pandey, A., Werner, Jr. J. K., Juluri, K. R., Xu, Y., Prestwich, G. D., Parang, K., Snyder, S. H. Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc. Nat. Acad. Sci. U.S.A. (2007) 104, 15305-15310.

10. Ye, G., Nam, N. H., Saleh,A., Kumar, A., Sun, G., Shenoy, D. B., Amiji, M. M., Parang,K. Cellular delivery of phosphopeptides with tripodal peptide analogues. J. Med. Chem. (2007) 50, 3604-3617.

11. Ahmadibeni, Y., Parang, K., Synthesis and evaluation of oligodeoxynucleotides containing diphosphodiester internucleotide linkages. Angew. Chem. Int. Ed. (2007) 46, 4739-4743.

12. Gu, X., Wang, Y., Kumar, A., Ye, G., Parang, K., Sun,G. Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase. J. Med. Chem. (2006) 49, 7532-7539.

13. Kumar, A., Ye, G., Wang, Y., Lin, X., Sun, G., Parang, K. Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogs of CIYKYY as Src tyrosine kinase inhibitors. J. Med. Chem. (2006) 49, 3395-3401.14. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of dinucleoside and nucleoside-carbohydrate phosphodiesters and thiophosphodiesters. J. Org. Chem. (2006) 71, 6693-6696.

15. Ahmadibeni, Y., Parang, K. Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides. Org. Lett. (2005) 7, 5589-5592.

16. Ayrapetov, M. K., Nam, N. H., Ye, G. Kumar, A., Parang, K., Sun, G. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation. J. Biol. Chem. (2005) 280, 25780-25787.

17. Nam, N.-H., Ye, G., Sun, G., Parang, K. Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding. J. Med. Chem. (2004) 47, 3131-3141.

18. Force, T., Kuida, K., Parang, K., Kyriakis, J. M. Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation (2004) 109, 1196-1205.

19. Lee, S., Lin, X., Nam, N. H., Parang, K., Sun, G. Determination of the substrate-docking site of protein tyrosine kinase Csk. Proc. Nat. Acad. Sci. U.S.A. (2003) 100, 14707-14712.

20. Parang, K. Polymer-supported reagents for methylphosphorylation and phosphorylation of Carbohydrates. Bioorg. Med. Chem. Lett. (2002) 12, 1863-1866.

21. Parang, K., Till, J. H., Ablooglu, A. J., Kohanski, R. A., Hubbard, S. R., Cole, P. A.Mechanism-based design of a protein kinase inhibitor. Nature Structural Biology (2001) 8, 37-41.