Sara E. Rosenbaum, Ph.D.
Professor of Applied Pharmaceutical Sciences
sarar@uri.edu

Click here for information about Dr. Rosenbaum's lab

Education

• Ph.D., University of Liverpool, 1980

Research Interests:

Dr. Rosenbaum’s research interests are associated with understanding the dose response relationship and factors that effect this relationship. This area is studied through the development and application of pharmacokinetic and pharmacodynamic models.

Research techniques used include: the development of pharmacokinetic and pharmacodynamic models using traditional and population methods; testing various patient demographic characteristics as potential covariates for pharmacokinetic and/or pharmacodynamic parameters; screening  potential drug interactions; simulations using integrated pharmacokinetic-pharmacodynamic computer models to more clearly understand the relationship and the effect of the perturbations of various parameters on drug response.

1. Use of integrated pharmacokinetic-pharmacodynamic models to assess the impact of altered pharmacokinetic parameters. Detailed pharmacokinetic-pharmacodynamic models have been created. Simulations are being carried out to assess the importance of dose and pharmacodynamic parameters in determining the impact of altered pharmacokinetic parameters
2. Development of an integrated pharmacokinetic-pharmacodynamic model for the dose response relationship for warfarin. The study of the effect of variability among the drug’s various pharmacokinetic and pharmacodynamic parameters on the response as measured by the INR.
3. Development of a Population Pharmacokinetic Model  For Zidovudine.
4. Development of a Population model for Nelfinavir and the use of population pharmacokinetics to screen for drug-drug interactions.

Publications:

• Jackson, K., Rosenbaum, S.E., Yuen, G., Anderson, R., Dudley, M. and the AG 1343-511 Clinical Study Group. "Population Pharmacokinetics of  Nelfinavir in HIV Positive Patients." Abstract 12th World AIDS Conference, Geneva, 1998
• Rosenbaum, S.E. "Effect of Variability In Hepatic Clearance on the Bioequivalence Parameters of a Drug and its Metabolite: Simulations Using a Pharmacostatistical Model." Pharmaceutica Acta Helvetiae. 73:135-144. 1998.
• Generali, J., Danish, M. and Rosenbaum, S.E.  "Knowledge of and Attitudes About Adverse Drug Reaction Reporting Among Rhode Island Pharmacists."  The Annals of Pharmacother.  29:365-369 1995
• Rosenbaum, S.E., Carter, A. and Dudley, M.N. "Population Pharmacokinetics:  Fundamentals Principles and Applications." Drug Dev. Ind. Pharm.  21:1115-1141. 1995.
• Rosenbaum, S.E., Carter, A., Drusano, Dudley, M.N. & VA Cooperative Study #298. "Population Pharmacokinetics of Zidovudine in Symptomatic Patients with HIV-Infection." Abstracts of 35th ICAAC.  a10 2. 1995.

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