Postdoctoral Fellowship, University of
Kansas Medical Center, 2000-2004
Ph.D., University of CT, Pharmaceutical
Sciences (Pharmacology and Toxicology), 2000
B.S., University of CT, Molecular and
Cellular Biology, 1995
Research Interests:
Dr. Slitt's research interests focus on how
1) expression of drug transporters affects chemical (i.e. drug and
environmental chemical) disposition and toxicity, 2) nutrition and
intake of dietary antioxidants affects the expression of drug
transporters, 3) liver disease (i.e. diabetes, cholestasis, and ethanol
cirrohsis) affects transporter expression and chemical disposition, and
4) transporter expression affects cholesterol transport and
susceptibility to gallstone formation.
Publications:
37. Cheng, Q., Maher, J.M., Yamamoto, M.,
and Slitt, A.L., Role of KEAP1 in regulating expression of transporters
in liver. Submitted to Drug Metabolism Disposition
36. Merrell MD, Augustine LM, Slitt A.L., Cherrington NJ. Induction of
drug metabolism enzymes and transporters by oltipraz in rats. J Biochem
Mol Toxicol. 2008;22:128-35.
35. Augustine LM, Fisher CD, Lickteig AJ,
Aleksunes LM, Slitt A.L., Cherrington NJ.Gender divergent expression of
Nqo1 in Sprague Dawley and August Copenhagen x Irish rats. J Biochem Mol
Toxicol. 2008;22:93-100.
34. Cheng
Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, Yamasaki H,
and Slitt AL. Drug-metabolizing enzyme and transporter expression in a
mouse model of diabetes and obesity. Mol. Pharm., 2008, 5:77-91.
33. Ahern, L.D., Besselsen, D.G., Kulkarni,
S., Cheng, Q., Slitt, A.L., and Cherrington, N.J. Induction of Hepatic
Transporter Proteins Protects Against LCA-Induced Intrahepatic
Cholestasis, Toxicology and Applied Pharmacology, 2008, 226:74-83
32. Aleksunes, L.M.A, Slitt, A.L.,Maher,
J.M., Augustine, L.M., Goedken, M., Chan, J.Y., Cherrington, N.J.,
Klaassen, C.D., and Manautou, J.E. Induction of Mrp3 and Mrp4
transporters during acetaminophen hepatotoxicity is dependent on Nrf2
transcription factor. Toxicology and Applied Pharmacology, 2008,
226:74-83
31. Maher J.M., Dieter M.Z., Aleksunes L.M.,
Slitt A.L., Guo G., Tanaka Y., Scheffer G.L., Chan J.Y., Manautou J.E.,
Chen Y., Dalton T.P., Yamamoto M., Klaassen C.D. Oxidative and
electrophilic stress induces multidrug resistance-associated protein
transporters via the nuclear factor-E2-related factor-2 transcriptional
pathway. Hepatology. 2007, 46(5):1597-610.
30. Lickteig A.J., Fisher C.D., Augustine L.M., Aleksunes L.M.,
Besselsen D.G., Slitt A.L., Manautou J.E., Cherrington N.J. Efflux
Transporter Expression and Acetaminophen Metabolite Excretion are
Altered in Rodent Models of Non-Alcoholic Fatty Liver Disease. Drug
Metab Dispos. 2007, 35:1970-8.
For more
information, contact:
College of Pharmacy
Fogarty Hall, 41 Lower College Road, Kingston, RI 02881
Phone: 401-874-5842, Fax: 401-874-2181
E-mail:
pharmcol@etal.uri.edu.
The
University is an affirmative action/equal opportunity employer.
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