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Education

• Postdoctoral, Penn State University
• Ph.D., Texas A&M University, 2002
• B.S., John Brown University, 1996

Research Interests:

• Variations in human nuclear receptors that regulate expression of xenobiotic-responsive genes
• Mechanisms of estrogen-modulated gene expression in human hormone-responsive cancer cell lines.
• Regulation of gene expression by nuclear receptors under hypoxia versus normoxia

Publications:

• Auerbach, SS., Stoner, MA., Su, S. and Omiecinski, CJ. (2005). RXR-dependent transactivation by a naturally occurring structural variant of human CAR (NR1I3). Mol. Pharm. 68, 1239-1253.
• Stoner, M., Wormke, M., Saville, B. Samudio, I., Qin, C., Abdelrahim, M. and Safe, S. (2004). Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene 23(5), 1052-1063.
• Auerbach, SS., Ramsden, R., Stoner, MA., Verlinde, C., Hassett, C. and Omiecinski, CJ. (2003). Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Res. 31(12), 3194-3207.
• Wormke, M., Stoner, M., Saville, B., Walker, K., Abdelrahim, M., Burghardt, R. and Safe, S. (2003). The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Mol. Cell. Biol. 23(6),1843-185.
• Stoner, M., Saville, B. Wormke, M. Dean, D., Burghardt, R. and Safe, S. (2002). Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells. Mol. Endocrinol. 16(10),2231-2242.
• Saville, B., Poukka, H., Wormke, M., Janne, O., Palvimo, J., Stoner, M., Samudio, I., and Safe, S.  (2002). Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. J. Biol. Chem. 277, 2485-2497.
• Yoon, K, Pallaroni, L., Stoner, M., Gaido, K. and Safe, S.  (2001). Differential activation of wild-type and variant forms of estrogen receptor a by natural and synthetic estrogenic compounds using a promoter containing three estrogen-responsive elements. J. Steroid Biochem. Mol. Biol. 78, 25-32.
• Samudio, I., Vyhlidal, C., Wang, F., Stoner, M., Chen, I., Kladde, M., Barhoumi, R., Burghardt, R., Safe, S.  (2001). Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17b-estradiol. Endocrinol. 142(3), 1000-1008.
• Stoner, M., Wang, F., Wormke, M., Nguyen, T., Samudio, I., Vyhlidal, C., Marme, D., Finkenzeller, G., and Safe, S. (2000). Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor a and Sp3 proteins.  J. Biol. Chem. 275, 22769-22779.
• Wormke, M., Stoner, M., Saville, B., and Safe, S. (2000).  Crosstalk between estrogen receptor a and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes.  FEBS Lett. 478(1-2), 109-112.
• Dong, L., Wang, W., Wang, F., Stoner, M., Reed, J.C., Harigai, M., Samudio, I., Kladde, M.P., Vyhlidal, C., and Safe, S. (1999).  Mechanisms of transcriptional activation of bcl-2 gene expression by 17b-estradiol in breast cancer cells.  J. Biol. Chem. 274, 32099-32107.

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