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Daniel Udwary, Ph.D.
Assistant Professor of Pharmacognosy
danudwary@mail.uri.edu
Education:
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Postdoctoral
research, University of California San Diego, Scripps Institution of
Oceanography, 2005-2007.
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Postdoctoral
research, University of Arizona, College of Pharmacy, 2003-2005.
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Ph.D. in Bioorganic
Chemistry, The Johns Hopkins University, 2003.
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M.A. in Chemistry,
The Johns Hopkins University, 1999.
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B.S. in Chemistry,
University at Albany, 1996.
Research Interests:
My group will pursue the identification and
manipulation of natural product biosynthetic gene clusters for the
purpose of discovering and modifying molecules useful in medicine.
High-throughput genomic sequencing has led to new opportunities for drug
discovery in the use of bioinformatics to allow the prediction of
chemical structures using DNA sequence alone. My laboratory will employ
knowledge of natural products, genomics, enzymology, ecology, and
computational chemistry to develop new tools for analysis of
biosynthetic systems in newly sequenced microbial genomes, and to
catalog and compare the massive numbers of sequences publicly available.
By increasing our knowledge of these systems, we aim to develop
methodology to allow organic synthesis of complex drug-like molecules
using biological systems.
Publications:
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Schultz AW, Oh DC,
Carney JR, Williamson RT, Udwary DW, Jensen PR, Gould SJ, Fenical W,
Moore BS. Biosynthesis and structures of cyclomarins and cyclomarazines,
prenylated cyclic peptides of marine actinobacterial origin. J Am Chem
Soc. 2008 Apr 2;130(13):4507-16.
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Daniel W. Udwary,
Lisa Zeigler, Ratnakar N. Asolkar, Vasanth Singan, Alla Lapidus, William
Fenical, Paul Jensen, Bradley S. Moore. Genome sequencing reveals
complex secondary metabolome in the marine actinomycete Salinispora
tropica. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10376-81.
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Lijiang Song,
Francisco Barona-Gomez, Christophe Corre, Longkuan Xhang, Daniel W.
Udwary, Michael B. Austin, Joseph P. Noel, Bradley S. Moore and Gregory L.
Challis. Type III Polyketide Synthase ?-Ketoacyl-ACP Starter Unit and
Ethylmalonyl-CoA Extender Unit Selectivity Discovered by Streptomyces
coelicolor Genome Mining. J Am Chem Soc. 2006 Nov 22;128(46):14754-14755
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Crawford JM, Dancy
BCR, Hill EA, Udwary DW, Townsend CA. Identification of a
starter unit acyl-carrier protein transacylase domain in an iterative
type I polyketide synthase. Proc Natl Acad Sci U S A. 2006 Nov
7;103(45):16728-33.
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Austin MB, Izumikawa
M, Bowman ME, Udwary DW, Ferrer JL, Moore B, Noel JP. Crystal structure
of a bacterial type III polyketide synthase and enzymatic control of
reactive polyketide intermediates. J. Biol Chem. 2004 Oct
22;279(43):45162-74
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Udwary DW, Merski M,
Townsend CA. A method for prediction of linker regions within large
multi-functional proteins, and its application to a type I polyketide
synthase. J. Mol. Biol., 2002, 323, 585-598.
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Udwary DW, Casillas
LK, Townsend CA. Synthesis of 11-Hydroxyl O-Methylsterigmatocystin and
the role of a cytochrome P-450 in the final step of aflatoxin
biosynthesis, J. Am. Chem. Soc. 2002, 124, 5294-5303.
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