Bingfang Yan, Ph.D.

Professor of Pharmacology and Toxicology
Department of Biomedical and Pharmaceutical Sciences
byan@uri.edu

Publications | Referee | Honors & Awards
Conference Presenations | Invited Speaker

Click here for information about Dr. Yan's lab

Research Interests

• Genetic-based alteration on drug response
• Drugs, herbs, hormones, and their interaction
• Cancer: initiation, progression and chemoresistance
• Transcription regulation

Education

Ph.D., University of Kansas, 1994

Fellow, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 1989-1991

Fellow, Department of Microbiology and Immunology, New York Medical College, 1988-1989

M.S., Nanjing Agricultural University, 1985

D.V.M., Huazhong Agricultural School of Veterinary Medicine, 1982

Professor, University of Rhode Island, Department of Biomedical and Pharmaceutical Sciences; 2004-present

Leader of Functional Genomics and Proteomics, Rhode Island Biomedical Research Infrastructure Network; 2001-2005

Associate Professor, University of Rhode Island, Department of Biomedical Sciences; 2001-2004

Assistant Professor, University of Rhode Island, Department of Biomedical Sciences; 1997-2001

Research Assistant Professor, University of Kansas Medical Center, Department of Pharmacology, Toxicology and Therapeutics; 1991-1996

Assistant Professor, Huazhong Agricultural University, Microbiology and Immunology, School of Veterinary Medicine; 1987-1988

Instructor, Huazhong Agricultural University, Microbiology and Immunology, School of Veterinary Medicine; 1985-1987

Xie M, Yang D, Wu M, Xue B, Yan B (2003) Mouse carboxylesterase M-LK rapidly hydrolyzes antitumor prodrug CPT-11 and the N-terminal three quarter sequence determines substrate selectivity. Drug Metab Dispos.  31: 21-27.

Sachdeva K, Yan B, Chichester CO (2003) Lipopolysaccharide and cecal ligation/puncture differen­ti­ally affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target gene CYP3A. Shock. 19: 470-475.

Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 278: 16899-16907.

Wyde ME, Bartolucci E, Ueda A, Zhang H, Yan B, Negishi M, You L (2003) The environmental pollutant DDE induces hepatic cytochrome P450 2B and 3A expression through activating the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Mol Pharmacol. 64: 474-481.

Xie M, Yang D, Matoney L, Yan B (2003) Rat NTE-related esterase is a membrane-associated protein, hydrolyzes lipophilic esters and interacts with diisopropyl­fluoro­phosphate through serine catalytic machinery. Arch Biochem Biophys. 416: 137-146.

Nam NH, Pitts R, Sun G, Sardari S, Tiemo A, Xie M, Yan B, Parang K (2004) Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. Bioorgan & Med Chem. 12: 779-787.

Song X., Xie M, Zhang H, Li Y, Sachdeva K, Yan B (2004) The pregnane X receptor binds to response elements in a genomic context-dependent manner and its activator rifampicin selectively alters the bindings among target genes. Drug Metab Dispos. 32: 35-42.

Song X, Gragen S, Li Y, Ma Y, Liu J, Yang D, Matoney L, Yan B (2004) Intramolecular disulfide bridges are required for folding hydrolase B into a catalytically active conformation but not for maintaining it during catalysis. Biochem Biophys Res Commun. 319: 1072-1080.

Li Y, Song X, Ma Y, Liu J, Yang D, Yan B (2004) DNA binding, but not interaction with BmalI, is responsible for DEC1-mediated transcription regulation of the circadian gene Per1. Biochem J. 382: 895-904.

Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL (2004) Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 32: 348-58.

Ma Y, Sachdeva K, Liu J, Ford M, Yang D, Khan IA, Chichester CO, Yan B (2004) Desmethoxy­yangonin and dihydro­methysticin are two major pharmacological kavalactones with potent activity on the induction of cytochrome P4503A23. Drug Metab Dispos. 32: 1317-1324.

Song X, Li Y, Liu J, Mukundan M, Yan B (2005) Simultaneous substitution of phenylalaine-305 and aspartate-318 of rat PXR by the corresponding human residues abolishes the ability to transactivate the cytochrome P4503A23 promoter. J Pher Exp Ther. 312: 571-582.

Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan YS (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med. 15: 633-640.

Hokeness K, Qiu LH, Vezeridis M, Yan B, Mehta S, Wan YS (2005) Paclitaxel-induced apoptosis in cultured human keratinocytes is enhanced by IFN-g and is modulated by activation of caspase 8 and 3 with a concomitant down regulation of the AKT survival pathway. Oncology Report. 13: 965-969.

Pope CN, Karanth S, Liu J, Yan B (2005) Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul Toxicol. Pharm. 42: 62-69.

Ma Y, Song X, Sachdeva K, Liu J, Li Y, Yang D, Deng R, Chichester CO, Yan B (2005) Clofibrate and perfluorodecanoate both up-regulate the expression of the pregnane X receptor but only clofibrate enhances its ligand-dependent induction of cytochrome P4503A23. Biochem Pharmacol. 69: 1363-1371.

Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, Bartolucci-Page E, Gaido KW, Yan B, You L (2005) Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses. Toxicol Sci. 86: 281-290.

Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan Y (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med. 15: 633-640.

Qiu L, Wang Q, Di W, Jiang Q, Schefeller E, Derby S, Wanebo H, Yan B, Wan Y (2005) Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. Int J Oncol. 27: 823-30.

Qiu L, Di W, Jiang Q, Scheffler E, Derby S, Yang J, Kouttab N, Wanebo H, Yan B, Wan Y (2005) Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. Int J Oncol. 27: 1441-8.

Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2005) The expression of antiapoptotic protein survivin is trans­criptionally upregulated by DEC1 primarily through multiple Sp1 binding sites in the proximal promoter.  Oncogene. In press.     

Deng R, Yang D, Yang J, Yan B (2005) Cholesterol oxylsterol transcriptionally induces the expression of the bile salt efflux pump through the farnesoid X receptor but not the liver X receptor. J Pher Exp Ther. Accepted.

Gong X, Tsai SW, Yan B, Rubin LP (2006) PPARg is essential but not sufficient to activate human intestinal b,b,-carotene 15,15’-oxygenase gene expression: role of MEF2C. J Biol Chem. Submitted.

Yan B (1988) Lecture 1: Introduction in Veterinary Epidemiology. Chinese J Vet Med. 14(5): 43-44.

Yan B (1988) Lecture 2: Conditions of Pathogenesis in Veterinary Epidemiology. Chinese J Vet Med. 14(6): 55-56.

Yan B (1988) Lecture 3: Distribution of Diseases in Veterinary Epidemiology. Chinese J Vet Med. 14(8): 52-53.

Yan B (1988) Lecture 4: Statistics in Veterinary Epidemiology. Chinese J Vet Med. 14(9): 46-48.

Yan B (1988) Lecture 5: Methodology in Veterinary Epidemiology. Chinese J Vet Med. 14(10): 41-43.

Yan B (1988) Lecture 6: Epidemiologic Modeling in Veterinary Epidemiology. Chinese J Vet Med. 14(11): 46-48.

Zheng H and Yan B (2001) Molecular Toxicology in Toxicology (Editor: Lijie Fu), pages 165-188, Shanghai Scientific Press, Shanghai.

Yan B (2004) Introduction to molecular biology and techniques in Molecular Neurotoxicology: Transcription and Signaling Targets (Editor: Nasser Zawia), pages 9-34, CRC Press, Florida.

1. Yan B, Morgan EW, Parkinson A (1990) Immunocytochemical localization of two carboxylesterases in rat liver, kidney and testis. Toxicologist 10: 323.

2. Morgan EW, Yan B, Parkinson A (1990) Purification and characterization of two rat liver microsomal carboxylesterases: studies on their regulation and tissue distribution. Presented at the VIIIth International Symposium on Microsomes and Drug Oxidation, Stockholm, Sweden. 

3. Yan B, Morgan EW, Parkinson A (1991) Carboxylesterase activities in human liver, kidney and testis. Toxicologist 11: 228.

4. Yan B, Brady M, Parkinson A (1992) Comparison of rat liver and testicular carboxylesterase by recombinant DNA techniques. Toxicologist 12: 330.

5. Yan B, Brady M, Parkinson A (1993) Nucleotide sequencing of a cDNA encoding a carboxylesterase present in rat liver and kidney microsomes. Toxicologist 13: 385.

6. Yan B, Yang D, Parkinson A (1994) Cloning and nucleotide sequencing of a rat liver carboxylesterase. Toxicologist 14: 1300.

7. Downing GJ, Yan B, Poisner A (1994) ß-Adrenoceptor activation stimulates human placental renin gene expression. Research Forum KUMC 22: 1.

8. Yan B, Parkinson A (1994) Identification of a secretory form of carboxylesterase in rat liver.  Research Forum KUMC 22: 39.

9. Parkinson A, Yan B (1994) Purification and cloning of rat carboxylesterases. International Conference of Microsomal Enzymes 12: 7.

10. Yan B, Yang D, Parkinson A (1995) Molecular biology of rat liver carboxyl­esterases. Toxicologist 15: 822.

11. Yang D, Yan B, Parkinson A (1995) Cloning and expression of hydrolase S, a serum carboxylesterase secreted by rat liver. Toxicologist 15: 824.

12. Fan F, Yan B, Wood G, Viluksela M, Rozman RR (1996) Cytokines (IL-1ß and TNF-a) in relation to biochemical and immunological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Toxicologist 16: 797.

13. Yan B, Parkinson A (1996) Structure of carboxylesterases and molecular basis for multiple forms. ISSX Proceedings 10: 6.

14. Hamilton GA, Oberfield JL, Moore LB, Jolly S, Coon DJ, McKee DD, Lehmann JM, Moore JT, Yan B, Laethem RM, Kliewer SA, LeCluyse EL (1999) PXR-mediated species difference in CYP3A gene regulation. ISSX Proceedings 13: 45.

15. Zhang H, Li Y, Yan B (1999) transactivation activity of rat PXR and the corresponding chimeric receptor. Northeast Society of Pharmacology 26.

16. Zhang H, Song L, Liu L, Matoney L, Yan B (2000) Immunochemical characterization of rat pregnane X receptor. Toxicologist 20: 498.

17. Zhu W, Song L, Li Y, Zhang H, Matoney L, Yan B (2000) Non-lytic expression of xenobiotic-metabolizing enzymes in insect cells. Toxicologist 20: 1750.

18. Zhang H, Li Y, Matoney L, Yan B (2000) A truncated PXR mutant potentiates the transactivation activity of the corresponding wild type PXR. ASBMB/ASPET. L106.

19. Chichester C, Sachdeva K, McKindley D, Zhang H, Li Y, Yan B (2000) Effect of LPS mediated blockade of PXR Translocation on CYP3A expression. Annual Shock Meeting. 

20. Zhang H, Yan B (2001) Human and rat pregnane X receptors differentially activate synthetic reporter genes. Toxicologist 40: 179.

21. Yang D, Li Y, Yuan X, Matoney L, Yan B (2001) Regulation of rat carboxylesterase expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves multiple signaling pathways. Toxicologist 40: 2117.

22. Li Y, Jones B, Wan Y, Zhang H, Yan B (2001) Effect of UVB irradiation on the expression of skin drug-metabolizing enzymes Toxicologist 40: 294.

23. You L, Bartolucci E, Fryczynski M, Zhang H, Yan B (2001) DDE activates the orphan nuclear receptor PXR and induces 6beta-testosterone hydroxylase. 83rd Endocrine Society Annual Meeting. P3-653.

24. Yang D, Yan B (2002) Mouse carboxylesterases M-LK and TGH: molecular cloning, tissue distribution, xenobiotic regulation and evidence for the N-terminal sequence to determine the substrate specificity. Toxicologist 41: LB135.

25. Xie M, Yan B (2002) Responsiveness of heat shock protein genes to a range of herbal supplements. Toxicologist 41: 933.

26. Zhang W, Yan B (2002) Human and rodent carboxylesterases: immunorelatedness, overlapping sub­strate specificity, differential sensitivity to serine inhibitors, and tumor-related expression. Toxicologist 41: LB 134.

27. Zhang H, Yan B (2002) The N-terminal region of rat pregnane X receptor potentiates the transcription of the wild-type receptor and corepressor SuncoR reverses the potentiation effect. Toxicologist 41: 202.

28. Li Y, Xie M, Yan B (2002) DEC1 basic helix-loop-helix differentially regulates genes encoding carboxylesterases and cytochrome P450. Toxicologist 41: 200.

29. Wan YS, Yan B (2002) Utilization of Chinese herbs to attenuate cell signalings important for cancer development. International Conference on Chinese Medicine, Chengdu, China

30. Chiu C, Turlington A, Blanco M, Myne P, Lin JY, Yan B, Vezeridis M, Wan YS (2003) Ovarian cancer cells do not migrate in response to EGF largely due to the inactivation of ERK. AACR Annual Meeting

31. Nam NH, Pitts R, Sun G, Sardari S, Tiemo A, Xie M, Yan B, Parang K (2003) Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. Cordon Research Conference on Bioorganic Chemistry.

32. Song X, Yan B (2003) The pregnane X receptor binds to response elements in genomic context and activator-dependent manners. International Society for the Study of Xenobiotics. 227.

33. Wan Y, Yan B (2003) Intramolecular disulfide bridges are required for folding hydrolase B into a cataly­ti­cally active conformation. International Society for the Study of Xenobiotics. 228.

34. Gragen SM, Yan B (2003) Selective hydrolysis of RAR activator tazarotene by human skin carboxyl­esterases. International Society for the Study of Xenobiotics. 229.

35. Li Y, Sachdeva K, Yan B, Chichester CO (2003) Clofibrate synergistically increases the induction of CYP3A1/23 by pregnenolone 16a-carbonitrile. International Society for the Study of Xenobiotics. 230.

36. Xie M, Yan B (2003) Rat NTE-related esterase hydrolyzes phenyl valerate through a serine catalytic machinery. International Society for the Study of Xenobiotics. 231.

37. Sachdeva K, Yan B, Chichester CO (2003) Kavalactones differentially induce cytochrome P4503A1/23 and activate the pregnane X receptor.  International Society for the Study of Xenobiotics. 232.

38. Li Y, Wyde M, Kirwan S, Laughter A, Bartolucci-Page E, Gaido K, Yan B (2004) Di-butyl phthalate activates the nuclear receptors CAR and PXR and enhancers the expression of CYP2B1 and 3A1 in maternal and fetal liver in the rat. Toxicologist 43: 1374.

39. Pope C, Karanth S, Liu J, Shaikh J, Yan B (2004) Human liver carboxylesterase during postnatal maturation and its sensitivity to chlorpyrifos oxon. Toxicologist 43: 1840.

40. Xia JP, Song XZ, Bi ZG, Yan B, Wan YS (2004) EGCG inhibits UV-induced kB nuclear translocation and IL-6 secretion in cultured human keratinocytes. Annual Meeting of Society of Investigative Dermatology.

41. Q Wang, ZG Bi, Yan B, Wan YS (2004) Construction of full length cDNA differential display libraries for genital warts based on long template PCR and full-length cDNA suppression subtractive hybridization (FL-cDNA-SSH). Annual Meeting of Society of Investigative Dermatology.

42. Wang F, Bi ZG, Wang Q, Li GF, Wang XJ, Zhang ZS, Yan B, Wan YS (2004) Cloning and Expression of E6 and E7 Gene of Human Papilloma Virus Type II in E. coli. Annual Meeting of Society of Investigative Dermatology.

43. Sun WL, Bi ZG, Yan B, Wan YS(2004) Evaluation of histamine-releasing activity in the sera of patients with chronic urticaria. Annual Meeting of Society of Investigative Dermatology.

44. Song ZS, Xia JP, Bi ZG, Yan B, Wan YS (2004) Aloin attenuates UVA-induced AP1 activation and MMP expression in cultured human skin fibroblasts. Annual Meeting of Society of Investigative Dermatology.

45. Turlington A, Chiu C, Myne P, Bi ZG, Li Y, Yan B, Wan YS (2004) Reciprocal regulation of DEC1 and HIF1a in response to UV irradiation in cultured human Keratinocytes. Annual Meeting of Society of Investigative Dermatology. 

46. Turlington A, Myne P, Chiu C, Blanco A, Bi ZG, Yan B, Wan YS (2004) Insensitivity to oxidative stress and hyper-activation of AKT contribute to anomalous invasiveness of human melanoma cells. Annual Meeting of Society of Investigative Dermatology.

47. Fan WX, Zhou NH, Bi ZG, Yan B, Wan YS (2004) Expression of pIRES2-EGFP-hVEGF165 in HaCaT cells and pig hair pappilae cells. Annual Meeting of Society of Investigative Dermatology.

48. Wan YS, Yan B (2004) Selective Hydrolysis of RAR Activator Tazarotene By Human Skin Carboxylesterase. Annual Meeting of Society of Investigative Dermatology.

49. Yang J, Qiu L, Zhou C, Sheffler E, Derby S, Bi Z, Yan B, Wan Y (2005) DEC1 protects against UV-induced cell death in cultured human keratinocytes. Annual Meeting of Society of Investigative Dermatology.

50. Qiu L, Zhou C, Yang J, Sheffler E, Derby S, Bi Z, Yan B, Wanebo H, Wan Y (2005) Up-regulation of survivin mediated by transient activation of EGFR/AKT pathway contributes to reduced sensitivity of human melanoma cells to betulinic acid. Annual Meeting of Society of Investigative Dermatology.

51. Wang XY, Bi ZG, Yan B, Wan YS (2005) Protective effect of ()-epigallocatechin-3-gallate on UVA-induced inhibition of dermal fibroblasts collagen synthesis. Annual Meeting of Society of Investigative Dermatology.

52. Wang XY, Bi ZG, Yan B, Wan YS (2005) L-1 receptor antagonist inhibits MMP-1 production of UVA-irradiated human skin fibroblasts cultured with medium from UVB-irradiated keratinocytes. Annual Meeting of Society of Investigative Dermatology.

53. Wang XY, Bi ZG, Yan B, Wan YS (2005) IL-1 augments MMP-1 and MMP-2 production in UVA-irradiated human dermal fibroblasts. Annual Meeting of Society of Investigative Dermatology.

54. Wang XY, Bi ZG, Yan B, Wan YS (2005) The paracrine effect of UVB-irradiated human keratinocytes culture medium on MMP-1 production of UVA-irradiated dermal fibroblasts. Annual Meeting of Society of Investigative Dermatology.

55. Xiang W, Wang F, Bi ZG, Yan B, Wan YS (2005) Construction and expression of plasmid co-expressing human papillomavirus type 11 E7 and human IFNg-2b. Annual Meeting of Society of Investigative Dermatology.

56. Wang F, Bi ZG, Li GF, Wu HW, Wang Q, Liu F, Wang XJ, Zhang ZS, Yan B, Wan YS (2005)Generation of Recombinant Adenovirus Vectors of Human Papillomavirus Type 11 E7 Gene and Its Expression in Eukarytoic Cells. Annual Meeting of Society of Investigative Dermatology.

57. Wang P, Bi ZG, Jing J, He J, Yan B, Wan Y(2005) p16INK4a Protein expression and gene inactivation in human skin tumors. Annual Meeting of Society of Investigative Dermatology.

58. Chen B, Bi ZG, Yan B, Wan YS (2005) Protein profiling of human fibroblasts and keratinocytes by two dimensional gel electrophoresis. Annual Meeting of Society of Investigative Dermatology.

1. New York Medical College, NY (1989): Construction and differential screening of two cDNA libraries derived from melanoma cell lines.

2. University of Kansas Medical Center, KS (1993): Molecular cloning and expression of rat carboxylesterases.

3. University of Kansas Medical Center, KS (1994): Molecular biology of carboxyl­esterases in rat.

4. University of Kansas Medical Center, KS (1994): Identification of a secretory form of carboxylesterase synthesized in rat liver.

5. University of Kansas Medical Center, KS (1994): Approaches to search response genes.

6. University of Kansas Medical Center, KS (1995): Molecular basis for the existence of multiple forms of rat carboxylesterases.

7. Auburn University, AL (1995): Rat Carboxylesterases: Molecular basis for multiplicity and relationship to acetyl­cholin­esterases.

8. 7th North American ISSX Meeting (1996): Structure of carboxylesterases and the molecular basis for multiple forms (symposium).

9. Huazhong Agricultural University (1999): Mammalian carboxylesterases: structure, biosynthesis and xenobiotic regulation.

10. Life Science and Clinical Medicine in Beijing (2000): Pregnane X receptor mediated regulation of genes encoding drug-metabolizing enzymes.

11. Beijing Medical University (2000) Signaling of pregnane X receptor requires involvement of multiple nuclear proteins.

12. Pfizer Corporation (2000) Toxicological significance of carboxylesterase and signaling of pregnane X receptor.

13. Chemical Institute of Industrial Toxicology (2000) Role of the pregnane X receptor in cytochrome P450 induction.

14. University of Rhode Island, Department of Biochemistry, Microbiology and Molecular Genetics (2000) Receptor mediated induction of drug-metabolizing enzymes.

15. Avon Products Inc. (2000) Application of promoter reporter arrays in screening drug candidate compounds.

16. MultiCell Associates, Inc. (2001) Xenobiotic regulation of drug-metabolizing enzymes in primary and continuous cells.

17. Sino-American Pharmaceutical Professionals Association (2001) Regulation of Drug-metabolizing enzymes by nuclear receptor activation: serious consideration in drug development.

18. Unilever Inc. (2001) Skin signaling and assays for cosmetic products development.

19. Chinese Academy of Sciences (2001) Signaling of nuclear receptors in responding to drug and environmental chemicals.

20. Rhode Island Hospital (2001) Signaling of liganded and unliganded transcription factors: the pregnane X receptor in xenobiotic response and colon carcinoma associate factor in oncogenesis.

21. Providence College (2002) Oncogenic significance of DEC1 transcription factor.

22. Rhode Island Biomedical Infrastructural Network (2003) Roles of DEC transcription factors.

23. Rhode Island Hospital/Brown University, Department of Surgery (2003) The Pregnane X Receptor: Beyond drug-metabolism.

24. Rhode Island Hospital/Brown Medical School, Department of Orthopaedic Biology (2003) DEC trans­cription factors: Do it all.

25. Huazhong Agricultural University (2004) Signaling of PXR and DEC1 transcription factors.

26. Asian-Pacific Conference on Tumor Biology and Makers (2004) Oncogenic involvement of DEC1 transcription factor

27. Beijing University School of Medicine (2004) Natural products: Where we go from here?

28. University of Rhode Island, College of Pharmacy (2005) Genomic and structural bases for drug-drug interactions and oncogenic involvement of DEC1 transcription factor

29. CellzDirect Biotechology (2005) Prediction of pharmacokinetic interactions based on hydrolytic biotransformation

30. University of Rhode Island, Department of Biomedical & Pharmaceutical Sciences (2005) Hydrolytic biotransfor­ma­tion of aspirin (Pharmaceutical seminar series)

31. University of Kansas Medical Center (2005) Pharmacogenes: what are they?

32. Roger Williams Medical Center, COBRE/Research Department Seminar Series (2005) Molecular clock and oncogenesis: Is there a connection?