B.S., University of
Massachusetts, Amherst, MA,1984
Research Interests:
The
developmental-basis of adult diseases.
Environmental risk
factors for Alzheimer’s disease
Pinpointing
potential biomarkers for Alzheimer’s disease.
Developing drugs for
the treatment of neurodegenerative diseases.
Publications (last five years):
Riyaz Basha, Md.,
Wei, W., Brydie, M, Razmiafshari, M. and Zawia, N.H. (2003). Lead
induced developmental perturbations in hippocampal Sp1 DNA-biding are
prevented by Zinc. In vivo evidence for Pb and Zinc competition.
Intl. J. Devl. NeuroSci, 21(1): 1-12, 2003.
Atkins, D.S., Riyaz
Basha, Md. and Zawia, N.H.
Intracellular signaling pathways involved in mediating the effects of
lead on the transcription factor Sp1. Intl. J. Devl. NeuroSci,
21(5): 235-244, 2003.
Md. Riyaz
Basha, Wei, W. and Zawia, N.H. (2003). PCBs and
environmental metal Pb exacerbate b-amyloid aggregation and its
cytotoxicity in PC12 cells.Ogranohalogen Compounds, 65:
12-15.
Zawia, N. H.,
Riyaz Basha, Md., and Razmiafshari, M. An electrophoretic method to
determine the ability of xenobiotic metals to bind a specific protein
domain. Current Protocols in Toxicology 12. 11: 1-8, 2003.
Riyaz Basha, Md.,Wei, W., Reddy, G. R. and Zawia, N. H. Zinc finger
transcription factors mediate perturbations of brain gene expression
ilucidated by heavy metals. In: Molecular Nerotoxicology
Environmental Agents and Transcription-Transduction Coupling,
(Ed. N. H. Zawia), pp 43-64. CRC press, USA, 2004.
Basha, M.R., Wei,
W., Bakheet, S.A., Benitez, N., Siddiqi, H.K., Ge,
Y.W., Lahiri, D. K., and Zawia, N.H. The Fetal-basis of
Amyloidogenesis: Exposure to Lead (Pb) and Latent Over-expression of APP
and β-Amyloid in the Aging Brain. Journal of Neuroscience, 25:
823-829, 2005.
Basha, M.R., Murali,
M., Siddiqi, K.K., Ghosal, K., Siddiqi, O.K., Lashuel, H.A., Ge, Y.W.,
Lahiri D.K., and N. H. Zawia (2005). Lead (Pb) exposure and its
effect on APP proteolysis and Aβ aggregation, FASEB J. 19(14):
2083-2084, 2005.
Zawia, N. H. and
Basha, M.R.
Environmental Risk Factors and the Developmental-Basis for Alzheimer's
disease. Rev Neurosci. 16: 325-337, 2005.
Lahiri, D. K., Ge,
Y-W., Maloney, B., Thiel, G., Zawia, N.H., Geig, N.H., Sabamurti,
K. (2005). Functional and structural domains of the 5’-flanking regions
of the BACE1 gene promoter: implications in Alzheimer’s disease. In (Ed:
Fisher, A., Hanin I., Memo, M., and Stocchi, F.) New Trends in
Alzheimer and Parkinson Related Disorders: ADPD 2005, pp7-14.
Donohue, M., Wei,
W,, Wu, J., Zawia, N.H., Hud, N., Jesus, V.D., Schmechel, D.,
Hettick, J.M., Beezhold, D.H., and Vesper. S. Characterization of
nigerlysin (c), hemolysin produced by Aspergillus niger, and effect on
mouse neuronal cells in vitro. Toxicology. 219(1-3):150-155,
2006.
Basha, M.R., Brady,
N., Zawia, N.H., and
Kodavanti, P.R.S. Perinatal exposure to PCBs alters the activity of
transcription factors in the brain. Neurotoxicology, 27: 118-124,
2006.
Bolin, C.S., Basha,
M.R., Cox, D., Zawia, N. H., Maloney, B., Lahiri, D. K., and
Cardozo-Pelaez, F. (2006). Exposure to lead (Pb) and the developmental
origin of oxidative DNA damage in the aging brain. FASEB J.
20(6); 788-790.
Lahiri, Debomoy K,
Yuan-Wen Ge, Md Basha Riyaz, Bryan Maloney, De-Mao Chen and Nasser
Zawia. "Genetics & Epigenetic Studies in AD (Abstract)." Alzheimer's
and Dementia. 2(3,Suppl):S24. July 2006.
Lashuel, Hilal A.
and Nasser Zawia. "Islam: Governments Need to Reform Education
and Build a Scientific Culture." Nature. 444(7109):545. November
30, 2006.
Lahiri, D.K.,
Maloney, B., Basha, M.R., Ge, Y.W. Zawia, N.H. How and when
environmental agents and dietary factors affect the course of
Alzheimer’s disease: the “LEARn” model (Latent Early Associated
Regulation) may explain the triggering of AD. Curr. Alzheimer’s
Res., 4, 219-228, 2006. 95(2): 436-42.
Bakheet SA, Basha
MR, Cai H, Zawia NH. Lead exposure: expression and activity
levels of Oct-2 in the developing rat brain. Toxicological
Sciences
2007 95(2):436-442.
Stevens, K.E., Bunch
R.W., Anchordoquy, T.J., Zawia, N.H.,
Zheng, L., Abrams, D.J. An initial animal proof-of-concept study
for central administration of clozapine in schizophrenia patients.
Schizophrenia Bull., 33:479-480, 2007
Dosunmu R, Wu, J.,
Basha M.R., and Zawia, N.H.
Environmental and Dietary Risk Factors in Alzheimer’s disease: An
Overview. Expert Review of Neurotherapeutics. 7, 887-900,
2007.
White, L.D.,Cory-Slechta, D.A., Gilbert, M.E., Tiffany-Castiglioni, E.,
Zawia, N.H., Virgolini, M., Rossi-George, A., Lasley, S.M.,
Qian, Y., Basha, M.R. New concepts in the neurotoxicology of lead (Pb).
Toxicol. Applied Pharmacol. 225, 1-27, 2007 .
Jinfang Wu, Md.
Riyaz Basha, Brian Brock, David P. Cox, Fernando Cardozo-Pelaez,
Christopher A. McPherson, Jean Harry, Deborah C. Rice, Bryan Maloney,
Demao Chen, Debomoy K. Lahiri, and Nasser H. Zawia.
Alteration of Alzheimer disease (AD)-like pathology in aged monkeys
after infantile exposure to environmental lead (Pb): Evidence for a
developmental origin and environmental link for AD. J. Neurosci.
28:3-9, 2008.
Brock B., Basha,
M.R., dePalma, K., Harry, G., Rice, D.C., Zawia, N.H.
Immunohistochemical characterization of cerebral APP and Sp1 and its
relationship to amyloidogenesis. J. Alzheimer’s Dis.
13:71-80, 2008.
Daniel J Abrams, MD;
Lijun Zheng, MS; Kevin S Choo, MS; Jun J Yang, MS; Wei Wei, MD; Thomas J
Anchordoquy, PhD; Nasser H Zawia, PhD; Karen E Stevens, PhD, An
Initial Animal Proof-of-Concept Study for Central Administration of
Clozapine to Schizophrenia Patients. Schizophr Res. 100:86-96,
2008.
Joyce E. Royland ,
Jinfang Wu, Nasser H. Zawia , Prasada Rao S. Kodavanti, Gene
expression profiles in the cerebellum and hippocampus following exposure
to a neurotoxicant, Aroclor 1254: Developmental effects, Toxicol.
Appl. Pharmacol. (2008), doi:10.1016/j.taap.2008.04.022
For more
information, contact:
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Fogarty Hall, 41 Lower College Road, Kingston, RI 02881
Phone: 401-874-5842, Fax: 401-874-2181
E-mail:
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