Skip to main content
Faculty and Staff
Zawia  

Nasser H. Zawia, Ph.D.

Professor of Pharmacology and Toxicology
Department of Biomedical and Pharmaceutical Sciences
nzawia@uri.edu

Click here for information about Dr. Zawia's lab
     

Research Interests

  
  • The developmental-basis of adult diseases.
  • Environmental risk factors for Alzheimer’s disease
  • Pinpointing potential biomarkers for Alzheimer’s disease.
  • Developing drugs for the treatment of neurodegenerative diseases
     

Education

  

Ph.D., University of California, Irvine, CA,1989

M.S., Loma Linda University, Loma Linda, CA, 1986

B.S., University of Massachusetts, Amherst, MA,1984

     
Selected Publications  

Lahiri DK, Maloney B, Zawia NH. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Mol Psychiatry. 2009;14(11):992-1003.

Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, Harry GJ, Rice DC, Zawia NH, Lahiri DK. Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. J Alzheimers Dis. 2009;18(1):211-30.

Zawia NH, Lahiri DK, Cardozo-Pelaez F. Epigenetics, oxidative stress, and Alzheimer disease. Free Radic Biol Med. 2009; 46(9):1241-9.

Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology. 2008; 9(6):375-9.

Royland JE, Wu J, Zawia NH, Kodavanti PR.Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: developmental effects. Toxicol Appl Pharmacol. 2008;231(2):165-78.

Brock B, Basha R, DiPalma K, Anderson A, Harry GJ, Rice DC, Maloney B, Lahiri DK, Zawia NH. Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. J Alzheimers Dis. 2008;13(1):71-80.

Abrams DJ, Zheng L, Choo KS, Yang JJ, Wei W, Anchordoquy TJ, Zawia NH, Stevens KE. An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophr Res. 2008;100(1-3):86-96.

Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci. 2008; 28(1):3-9.

Wu J, Basha MR, Zawia NH. The environment, epigenetics and amyloidogenesis. J Mol Neurosci. 2008; 34(1):1-7.

White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian YC, Basha MR. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol. 2007;225(1):1-27.

Dosunmu R, Wu J, Basha MR, Zawia NH. Environmental and dietary risk factors in Alzheimer's disease. Expert Rev Neurother. 2007;7(7):887-900.

Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Curr Alzheimer Res. 2007;4(2):219-28.

Bakheet SA, Basha MR, Cai H, Zawia NH. Lead exposure: expression and activity levels of Oct-2 in the developing rat brain. Toxicol Sci. 2007;95(2):436-42.

Zawia NH, Basha MR. Environmental risk factors and the developmental basis for Alzheimer's disease. Rev Neurosci. 2005;16(4):325-37.

Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK, Cardozo-Pelaez F. Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. FASEB J. 2006;20(6):788-90.

Donohue M, Wei W, Wu J, Zawia NH, Hud N, De Jesus V, Schmechel D, Hettick JM, Beezhold DH, Vesper S. Characterization of nigerlysin, hemolysin produced by Aspergillus niger, and effect on mouse neuronal cells in vitro. Toxicology. 2006;219(1-3):150-5.

Basha MR, Braddy NS, Zawia NH, Kodavanti PR. Ontogenetic alterations in prototypical transcription factors in the rat cerebellum and hippocampus following perinatal exposure to a commercial PCB mixture. Neurotoxicology. 2006;27(1):118-24.

Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci. 2005;25(4):823-9.

Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH. Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. FASEB J. 2005;19(14):2083-4.