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This movie shows the
spatial interactions between enzyme and substrate. These spatial
interactions define whether a given drug is metabolized by a given
enzyme and where on the molecule metabolism is likely to occur. The
movie allows the viewer to get inside the scene and follow the drug
warfarin as it moves into the active site pocket of the enzyme ready for
catalysis.
Animated movie showing how
diuretics work in the kidney.
The narrated movie
takes the viewer from the human silhouette down subsequent levels of
detail finally ending on the transporter proteins which are the direct
targets of most diuretic drugs. The movie is intended to show the flow
processes within the kidney including such aspects as filtration,
reabsorption, and excretion in the nephron. It also shows the molecular
sequence of ion transport, how the diuretics inhibit the reabsorption of
sodium, and the subsequent effects on other ions.
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