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IMODR: Basic Pharmacokinetic and Pharmacodynamic Models

The models presented here are incorporated into the textbook, Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook with Computer Simulations, S.E. Rosenbaum, John Wiley, Inc Hoboken, NJ, (2011). The chapter in the textbook corresponding to each model is shown in parenthesis.

1. Transporter Model (Chapter 2)
   











2. IV Bolus Injection in a One Compartment Model (Chapter 7)
   











3. IV Bolus Injection in a Two Compartment Model (Chapter 8)
   











4. Characteristics of First Order Absorption in a One Compartment Model (Chapter 9)
   











5. Intravenous Infusion: Constant Continuous Administration (Chapter 11)
   











6. The Infusion Challenge (Chapter 11)
   











7. Multiple IV Bolus Injections (Chapter 12)
   











8. Multiple Intermittent Short Infusions (Chapter 13)
   











9. Multiple Oral Doses (Chapter 14)
   











10. Nonlinear Pharmacokinetics (Chapter 15)
    











11. Sigmoidal Emax Model (Chapter 16)
    











12. Sigmoidal Emax Model With an Effect Compartment (Chapter 16)
    











13. Operational Model of Agonism (Chapter 17)
    











14. Indirect Effect Model I: Inhibition in kin (Chapter 17)
    











15. Indirect Effect Model II: Inhibition of kout (Chapter 17)
    











16. Indirect Effect Model III: Stimulation of kin (Chapter 17)
    











17. Indirect Effect Model IV: Stimulation of kout (Cchapter 17)
    











18. Transit Compartment (Chapter 17)
    











19. Hypothetical Antagonist Model For Tolerance (Chapter 17)
    











20. Precursor Pool Depletion Model For Tolerance (Chapter 17)
    











21. Irreversible Effects (Chapter 17)
    











22. Hematological Toxicity of Anticancer Drugs (Chapter 17)
    











23. Lipoamide Integrated PK-PD Model (Chapter 17)
    

Basic Pharmacokinetics and Pharmacodynamics

Sara Rosenbaum
Professor of Pharmacokinetics
College of Pharmacy
University of Rhode Island
41 Lower College Road
Kingston, RI 02881
sarar@uri.edu
Tel 401-874-5021 (w)