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Several types of
interactive models have been and are in the process of being created.
As outlined below each type of model has its own goals and objectives.
Where available, examples of completed models from each group are
provided.
Basic Concepts of
Pharmacokinetics and Pharmacodynamics
Models and an
accompanying workbook have been developed to teach the basic
principles of pharmacokinetics and pharmacodynamics. The models are
designed to combat the dry nature of traditional pharmacokinetic
presentations as well as to allow for self-study. Pharmacokinetic
principles are presented and demonstrated under the user’s control.
These materials are directed to health profession students who study
pharmacokinetics as part of their curriculum and are also ideally
suited to pharmaceutical scientists who have no or little background
in pharmacokinetics.
One and two-compartment pharmacokinetic models are covered, as are all
typical types of drug administration. Several pharmacodynamics models
are also presented. Challenge models have also been developed to test
the user’s grasp of the subject.
Downloadable Examples
To use the
following examples you will need to download and install the isee
player. Click
here to link to the isee systems website to download the player.
Once you have
installed the player download and install the models. They will
automatically install in the isee player's sample models folders.
IV Infusion in the One Compartment Model
presents the characteristics and concepts of constant
drug input. The typical profile is shown and the influence of the
primary parameters of clearance and volume of distribution are
displayed. The effect of a loading dose and the characteristics of the
profile after termination of drug input are demonstrated.
IV Challenge
is designed to test if a student understands the
concepts of constant drug input. Based on a drug’s therapeutic range
and pharmacokinetic parameters, the user has to develop an initial
dosing regimen for a patient. Feedback is provided in the form of
phone calls and Emails about the patients’ progress. During the course
of therapy several patient characteristics change and the user has to
respond when necessary to make dosage adjustments.
These two models are downloaded in a
single package:
iMODA Infusion
Challenge.exe
Clinical Pharmacokinetics
of Certain Key Drugs
Pharmacokinetic-based
dosage adjustment is necessary for drugs with both a narrow
therapeutic range and wide inter-patient variability in
pharmacokinetics. Models have been developed for some of these drugs.
The models illustrate the consequences of altered pharmacokinetics,
allow students to practice dosage-individualization and also to
provide a summary of the pharmacokinetic and pharmacodynamics
characteristics of the drugs.
Student Models
As part of the basic
pharmacokinetics course in the College, students are required to work
together in groups to develop a model of a narrow therapeutic range
drug.
Advanced models are
also created by Pharm.D. students undertaking final year rotations.
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