PK / PD Modeling and Simulation Group
Dr. Sara E. Rosenbaum, Ph.D.
Research | Teaching | Personnel
Teaching
Area Under the Curve
Windows Media Player Version Flash Version
Flash Videos
2-Compartment Model (J. Conley)
This video shows the relative distribution of a drug between the two compartments from the time the dose is injected until the dose is removed from the body. It also shows how the drug’s Vd changes from the time the dose is administered until distribution to the peripheral compartment is complete. Designed by Jarred Conley
Hysteresis (J. Conley)
This video shows the time course of the plasma concentration and drug concentration at the site of action after an oral dose. It also shows how response is related to the plasma concentration (hysteresis curve) the concentration at the site of action.
Interactive Models of Drug Action (iMODA)
Several types of interactive models have been and are in the process of being created. As outlined below each type of model has its own goals and objectives. Where available, examples of completed models from each group are provided.
Basic Concepts of Pharmacokinetics and Pharmacodynamics
Models and an accompanying workbook have been developed to teach the basic principles of pharmacokinetics and pharmacodynamics. The models are designed to combat the dry nature of traditional pharmacokinetic presentations as well as to allow for self-study. Pharmacokinetic principles are presented and demonstrated under the user’s control. These materials are directed to health profession students who study pharmacokinetics as part of their curriculum and are also ideally suited to pharmaceutical scientists who have no or little background in pharmacokinetics.
One and two-compartment pharmacokinetic models are covered, as are all typical types of drug administration. Several pharmacodynamics models are also presented. Challenge models have also been developed to test the user’s grasp of the subject.
Interactive Working Examples
Clinical Pharmacokinetics of Certain Key Drugs
Pharmacokinetic-based dosage adjustment is necessary for drugs with both a narrow therapeutic range and wide inter-patient variability in pharmacokinetics. Models have been developed for some of these drugs. The models illustrate the consequences of altered pharmacokinetics, allow students to practice dosage-individualization and also to provide a summary of the pharmacokinetic and pharmacodynamics characteristics of the drugs.
Student Models
As part of the basic pharmacokinetics course in the College, students are required to work together in groups to develop a model of a narrow therapeutic range drug.
Advanced models are also created by Pharm.D. students undertaking final year rotations.
