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College of Pharmacy - 2012 Frontiers in Pharmaceutical Sciences Conference

pharmacy conference

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Program Agenda

Friday, September 28, 2012
Start	Session Title
12:00pm	Early Registration - Visitors Center
2:30pm	On-Site Registration (CoP)
4:30-4:45pm	Conference Opening Ceremony Donald H. DeHayes, Provost and Vice President for Academic Affairs Dean Ronald Jordan
4:45-5:30pm	Featuring: Francisco A. Tomás-Barberán, Ph.D., Professor Department of Food Science & Technology Campus de Espinardo, Murcia, CEBAS-CSIC, Spain Natural Product Derived Gut Microbacteria Metabolites as Potential Drugs: The Case of Urolithins
5:30-6:30pm	Keynote Speaker: Chad A. Mirkin, Ph.D. Professor Materials Science and Engineering Director of the International Institute for Nanotechnology Northwestern University Spherical Nucleic Acid (SNA) Nanostructures: A New Platform for Intracellular Gene Regulation
6:30-8:30pm	Welcome Reception Passed Hors D'Oeuvres, Food Stations and Cash Bar

Saturday, September 29, 2012
Start	Presenter/Session Title
7:30am	Registration opens Continental Breakfest served
	Track 1 - Drug Discovery	Track 2 - Drug Development
	Presenter/Session Title	Presenter/Session Title
8:45-9:30am	Iqbal Choudhary, Ph.D., Director International Center for Chemical and Biological Sciences, University of Karachi, Pakistan Nature's Chemical Diversity Role in Drug Discovery and Development	Chandra Prakash, Ph.D., Senior Director Biogen Idec, USA The Strategies for Minimization of Bioactivation Potential in Drug Discovery and Development
9:30-10:15am	Ahmed Kamal, Ph.D., Outstanding Scientist CSIR-Indian Institute of Chemical Technology, [IICT], Tarnaka, India Challenges in the Development of Pyrrolobenzodiazepines as Anti-tumor Antibiotics	Brian Houston, Ph.D., DSc, Professor University of Manchester, UK Predictive Hepatocellular Activity: Cornerstone for PBPK Modeling
10:15-10:30am	Refreshment Break
10:30-11:15am	Young-Joon Surh, Ph.D., Professor Seoul National University, South Korea Phytopharmaceuticals: From Discovery to Therapeutic Applications	Tommy B. Andersson, Ph.D., Senior Principal Scientist DMPK Center of Excellence, CVGI iMed DMPK, AstraZeneca R&D, Mölndal, Sweden The Evolution of CYP Induction Models to Support Drug Development
11:15-12:00pm	Hermann Wätzig, Ph.D., Professor University of Braunschweig, Germany Proteomics and Interactomics in Drug Discovery or drug Development	Karthik Venkatakrishnan, Ph.D., Director Millennium Pharmaceuticals, Inc., USA Drug-Drug Interactions (DDIs) in the Development of Anticancer Drugs: Strategies for Risk Assessment, Management and Clinical Evaluation
12:00-1:00pm	Lunch and Concurrent Short Oral Talks Drug Development Track Only Group 1 Ajay Donepudi, URI Bisphenol A (BPA) Perinatal Exposure in Avy Mice Suppresses Metabolic Genes Involved in BPA Metabolism (12:00-12:15) Ashish Sarode, URI In Vitro Simulation of Dissolution, Precipitation, and Absorption Phenomena of BCS Class II API's from Amorphous Solid Dispersions in Order to Predict their Bioavailability Enhancement (12:15 - 12:30) Emine Yalcin, URI Sulfotransferase Expression and Activity is Altered in Liver Disease (12:30 - 12:45) Joyce Macwan, URI Physiologically-Based Pharmacokinetic (PBPK) Model for Prediction of Oral Pharmacokinetics of Atorvastatin (12:45 - 1:00) Group 2 H. Elsa Larson, URI Oral Pre-Exposure Prophylaxis to Prevent HIV-1 Infection in High-Risk Adults: Implications for Clinical Pharmacy Practice (12:00 - 12:15) Songhua Zhang, Epivax An Integrated Genomic and Immunoinformatic Approach to H. Pylori Vaccine Design (12:15 - 12:30) Frances Terry, Epivax In Vitro and In Vivo Validation of Factor VIII De-Immunization by T Cell Epitope Modification (12:30 - 12:45) Ying Qing Yu, Waters Biotherapeutic Protein Glycosylation Analysis Using UPLC/QT of MS (12:45 - 1:00)
	Track 1 - Drug Discovery	Track 2 - Drug Development
1:00-2:15pm	Keynote Speaker: Tej P. Singh, Ph.D. Professor Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India 1. Drug Discovery: Structure and Action of Bacterial Resistance Free Novel Protein Antibiotic-PGRP-S 2. Structure-based Drug design using proteins of Pro inflammatory Pathway as Targets	Pfizer Symposium: Advancements in human pharmacokinetics prediction beyond CYP enzymes: An industrial perpective Ayman El-Kattan pH-dependant solubility and permeability criteria for provisional The Biopharmaceutics Drug Disposition Classification System (BDDCS) (1:00 - 1:20) Emi Kimoto Characterization of hepatic transport and disposition of gemfibrozil and its metabolite, 1-o-ß-glucoronide, using sandwich-cultured human hepatocytes (1:20 - 1:40) Manthena Varma Mechanistic modeling to predict transporter- and enzyme- drug-drug interactions of repaglinide (1:40 - 2:00) Theunis C. Goosen Advances in UDP-glucuronosyltransferase (UGT) phenotyping and implications for drug-drug interaction studies (2:00 - 2:20)
2:15-3:00pm	Gerhard Wolber, Ph.D., Professor Freie University, Germany Virtual screening and activity profiling using 3D pharmacophores (2:15-2:40pm) Süreyya Ölgen Ph.D., Vice Dean, Professor Ankara University, Turkey Design and Synthesis of Novel Small Molecules as Src Kinase Inhibitors (2:40-3:00pm)	Matthias Schwab, M.D., Professor Institute of Clinical Pharmacology, University of Tübingen, Germany Pharmacogenomics of Uptake Transporters and Clinical Implications (2:20 - 3:00)
3:00-3:15pm	Refreshment Break
3:15-4:10pm	Mahesh K. Lakshman, Ph.D., Professor The City College of New York, New York, USA Synthesis of Azidopurine Nucleosides and their Ligation Reactions with Alkynes: Towards New Potential Pharmacological Agents (3:15-3:50pm) Megan Luther, Kerry LaPlante, Associate Professor University of Rhode Island Evaluating the Activity of Daptomycin and Linezolid in Combination with Rifampin or Gentamicin on Enterococcus Faecium in an In Vitro Pharmacodynamic Model Using Simulated Endocardial Vegetations (3:50-4:10pm)	Richard Lalonde *Pharm. D., VP and Global Head of Clinical Pharmacology, Pfizer Inc., USA* Modeling and Simulation in Clinical Drug Development
4:10-5:00pm	Michael Greenfield, Associate Professor Chemical Engineering, University of Rhode Island Molecular Simulations of Peptide Shape and Peptide-Substrate Interactions (4:10-4:25pm) Atia Alwuhab, Assistant Professor International Center for Chemical and Biological Sciences, Karachi, Pakistan Discovery of Novel Antiglycation Agent- An Approach Towards the Treatment of Late Diabetic Complications (4:25-4:40pm) Daniel Carney, Graduate Student, Department of Chemistry, Brown University Diversity Oriented Synthesis of Cyclic Acyldepsipeptide Antibiotics (4:40-4:50pm) Dana Francis, Graduate Student, Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University Alternative Avenues for p38 Inhibitor Development (4:50-5:00pm)	Pravin R. Chaturvedi, Ph.D. CEO, IndUS Pharmaceuticals Drug Development from the Prospect of Small Biotech Companies, USA (4:00 - 4:45)
5:00-7:00pm	Poster Session Reception
7:00pm	Dinner & Keynote Speaker Keynote Speaker: Christopher Walsh, Ph.D. Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology Harvard Medical School, USA Prospects for New Antibiotics: A Molecule-Centered Perspective *Continued Poster Session and Networking*

Sunday, September 30, 2012
Start	Presenter/Session Title
8:00am	Registration opens Continental Breakfast served
9:00-10:00am	Keynote Speaker: Nobel Laureate Thomas Steitz, Ph.D. Sterling Professor of Molecular Biophysics and Biochemistry Professor of Chemistry Investigator, Howard Hughes Medical Institute Yale University From the Structure and Function of the Ribosome to New Antibiotics
	Track 1 - Drug Discovery	Track 2 - Drug Development
	Presenter/Session Title	Presenter/Session Title
10:15-11:00am	Keynote Speaker: Jhillu Singh Yadav, Ph.D. Director Indian Institute of Chemical Technology, Hyderabad, India Natural Product Synthesis for Drug Discovery	David Greenblatt, M.D., *Louis Lasagna Professor of Pharmacology and Experimental Therapeutics, Tufts University, USA* Altered Drug Disposition and Response in Old Age: Experimental and Clinical Models
11:00-11:45am	Zhong Chen, Ph.D., Executive Dean of College of Pharmaceutical Science Vice Dean of School of Medicine Vice Director of Ministry of Health Key Lab of Neurobiology College of Pharmacy, Zhejiang University, China Effect of Histamine and its Receptors on Brain Ischemia and Designing Histamine 3 Antagonists	Ronald N. Hines, Ph.D., Professor Medical College of Wisconsin, USA Pharmacological Challenges During Early Life Stages
11:45-1:15pm	Lunch and Concurrent Short Oral Talks Drug Development Track Only Group 3 Mark Wrona, Waters Xenobiotic Metabolite Identification Using Integrated LCMS Database Software Tools (12:00 - 12:15) Michael Hanley, Tufts University Inhibition of Cytochrome P450 Enzymes by Fruit Juices: In Vitro Effects, Clinical Relevance, and Therapeutic Implications (12:15 - 12:30) Shripad Chitnis, URI Investigation of Sirolimus Pharmacokinetics and Expression of Selected CD19+ B-Cell Surface Markers in Diabetic Kidney Transplant Recipients (12:30 - 12:45) Supriya Kulkarni, URI Turning on the Sirtuin 1 Pathway to Reverse Drug Transporter and Nuclear Receptor Pathways in Fatty Liver (12:45 - 1:00) Swetha Rudraiah, University of Connecticut Mechanism of Flavin-Containing Monooxygenase-3 (FMO3) Gene Regulation During Acetaminophen Toxicity (1:00 - 1:15) Group 4 Joomi Ahn, Waters Fragment Antibody Binding to a Highly Conserved Influenza Epitope - An HDX Study (12:00 - 12:15) Lenny Moise, Epivax Immunoinformatic Identification of Cross-Conserved Pandemic Influenza H1N1 T-Cell Epitopes (12:15 - 12:30) Leslie Cousens, Epivax Tregitope Applications to Tolerance Induction in Autoimmune Diseases (12:30 - 12:45) Vijay More, URI Differential Hepatic and Intestinal Phase-II Biotransformation Enzyme/Transporter Expression and Bisphenol A Disposition in Mouse Models of Obesity and Diabetes (12:45 - 1:00) Swapnil Malekar, URI Design, Development and Comparison of Polyfunctional Polymersomes and Liposomes for Concurrent Delivery of Multiple Therapeutic and Diagnostic Agents (1:00 - 1:15)
	Track 1 - Drug Discovery	Track 2 - Drug Development
1:15-2:00pm	Ashok Prasad, Ph.D., Professor University of Delhi, India Glucose to Modified Nucleosides and Sugar PEG Based Co-Polymer for Drug Delivery Applications (1:15-1:45pm) Brenton DeBoeff, Department of Chemistry, URI Facile and Green Methods for the Synthesis of Heterocyclic Drug Scaffolds via Oxidative C-H Functionalization (1:45-2:00pm)	Vincent Pichette, M.D., Ph.D., Professor University of Montreal, Canada Impact of Kidney Disease on Drug Metabolism and Transport
2:00-2:45pm	Akhilesh K. Verma, Ph.D., Associate Professor University of Delhi, India Electrophilic Cyclization of Alkynes: A Modern Tool for the Synthesis of Small Heterocyclic Molecules of Pharmaceutical Interest (2:00-2:30pm) Mindy Levine, Department of Chemistry, URI Synthesis and DNA Binding of Chiral Cationic Polyamines (2:30-2:45pm)	Terry Smolarek, Ph.D., Senior Director Pfizer Research & Development, USA Ethnic Differences in Pharmacokinetics
2:45-3:30pm	Anil Kumar, Ph.D., Assistant Professor Birla Institute of Technology, Pilani, India Synthesis of Biologically Active Heterocyclic Compounds Employing Multicomponent Reactions (2:45-3:05pm) Sunil Sharma, Ph.D., Professor University of Delhi, India Ammonium Derivatives of Chromenones and Quinolinones as Lead Antimicrobial Agents (3:05-3:30pm)	Kazuya Maeda, Ph.D., Assistant Professor Graduate School of Pharmaceutical Sciences, University of Tokyo The Importance of OATP Transporters in the Clinical Pharmacokinetics of Anionic Drugs
3:40-4:30pm	Annie S. De Groot, M.D., Research Professor University of Rhode Island and Director, Institute for Immunology and Informatics, EpiVax, USA Is There No Balm in Bamako, Mali? Keeping Drug and Vaccine Development in Perspective (3:40 - 4:30)
4:30-4:40pm	Closing Remarks

Monday, October 1, 2012
Networking Events with International Speakers, Faculty Staff and Students

who should attend?

Drug discovery, delivery, and development scientists
Pharmaceutical scientists
Academic and industrial researchers
Students and postdoctoral fellows involved in pharmaceutical sciences

Registration

Attendee Registration

questions?

Please send an email to:

Dr. Keykavous Parang or Dr. Navindra Seeram at Frontiers@etal.uri.edu

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