Objective: To develop and integrate pharmacodynamic (PD) and pharmacokinetic (PK) models for specific drugs into a human infant patient simulator.

Step 1: Defining the Project

Develop the list of six drugs to be programmed for the BabySIM:

• Atropine
• Dopamine
• Epinephrine
• Fentanyl
• Morphine
• Succinylcholine

Step 2: Literature Search

• Undertook a comprehensive literature search for PD and PK values for the selected drugs.

Step 3: Data Collection/Interpretation

• Compiled published cardiac, hemodynamic and respiratory data needed to establish dose-response effects.
• Analyzed data using principles of compartmental modeling and dose-response effect to generate PK and PD parameters for use with the Drug Editor.
• Developed a summary document for each drug.

Step 4: Integrate Parameters into BabySIM

• Programmed PK and PD parameters into BabySIM using the Drug Editor.
• Confirmed PK drug profile using a Stella model developed by Dr. Rosenbaum.
• Compared the BabySIM response with documented biomedical literature.