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Normal Flow (Direct) Filtration

Course Outline

  • Fundamentals of normal flow filtration
  • Applications of filtration in a recombinant purification process:
    - Clarification
    - Prefiltration
    - Sterile filtration
    - Buffer filtration
    - Virus filtration
  • Types of membranes and media
  • Membrane Manufacturing methods
  • Types of membrane modules and cartridges
  • Fouling mechanisms
  • Vmax testing
  • Sizing of filters
    - based on throughput
    - based on flow rate
  • Integrity testing of filters
  • Practical tips on dos and don'ts